首页> 中文会议>2011年全国药物化学学术研讨会 >Creating Powerful Systematic Methods, Tools and Datasets for Understanding Human Biology and Disease and Applying Them to Leading-Edge Medical Challenges

Creating Powerful Systematic Methods, Tools and Datasets for Understanding Human Biology and Disease and Applying Them to Leading-Edge Medical Challenges

摘要

The increased understanding of how genomic changes contribute to disease through initiatives like The Cancer Genome Atlas (TCGA) has expanded important targets and pathways that are relevant to disease.Although the strength of the evidence is increasing that transcription factors, regulatory RNAs, protein/protein and protein/DNA interactions are critically involved in disease processes, these types of targets are often described as "undruggable" because they bear little resemblance to the approximately 500 targets of the current pharmacopeia.

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