The human brain contains billions of neurons to receive and integrate a host of elec-trical andbiochemical signals. Efficiency in communication among neurons is made po-ssible by synapses,contacts formed between two neurons. Despite significant progres-s in our understanding of synapseanatomy，relatively little is known about how diff-erent components/molecules are assembled togetherand how the disruption of this pro-cess and synapse function causes psychiatric and neurologicaldisorders. The focus o-f our lab is to understanding the mechanisms underlying synapse formation andwhat g-oes wrong at synapses under pathological conditions. Our studies aim at identificat-ion oftargets and development of potential therapeutic strategies for treating diso-rders whose pathogenesisinvolves abnormal synaptic structure and function. These i-nclude psychiatric disorders such asschizophrenia，autism，and depression and neuro-logical disorders such as muscular dystrophy，spinalcord injury，and epilepsy.
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机译：Three-dimensional collagen-based scaffold model to study the microenvironment and drug-resistance mechanisms of oropharyngeal squamous cell carcinomas
