Obesity is often associated with serious medical conditions such as metabolic syndrome, atherosclerosis, heart disease, and diabetes. In perioperative medicine,physicians including anesthesiologists often focus on obesity-related risks for airway management, respiration, and drug dosing, but little is known about obesity effects on perioperative pain. In this preclinical study, Long-Evans rats were fed a high fat (HF)diet (40% calories from fat, primarily butter fat ) for 6 weeks to induce obesity followed by hindpaw plantar incision (Brennan model of postoperative incisional pain). Mechanical and thermal pain sensitivity were assessed by measuring withdrawal thresholds (PWT) for up t0 2 weeks postoperatively.
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