首页> 外文会议>The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议)论文集 >Expression of human Differentiated embryochondrocyte expressed gene 1 in Gastric carcinoma and its correlation with STAT3
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Expression of human Differentiated embryochondrocyte expressed gene 1 in Gastric carcinoma and its correlation with STAT3

机译:人分化胚胎软骨细胞表达基因1在胃癌中的表达及其与STAT3的相关性

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DEC1, also known as SHARP-2 or Stra13, is an important molecule in embryonic differentiation and a bHLH type transcriptional regulator. It has recently been identified to be abundantly expressed in several human tumors and might play an important role in tumor development. But its expression in Gastric carcinoma is unknown. In this study we show that DEC1 was frequently expressed in six gastric carcinoma cell lines with different background and tumor tissues from patients with gastric carcinoma. A significant association of DEC1 expression with STAT3 expression was also proved. These findings suggest that DEC1 is strongly related with gastric carcinoma; it might play its role in tumor development through STAT3-signaling pathway.
机译:DEC1,也称为SHARP-2或Stra13,是胚胎分化中的重要分子,是bHLH型转录调节子。最近已确定它在几种人类肿瘤中大量表达,并可能在肿瘤发展中起重要作用。但是其在胃癌中的表达尚不清楚。在这项研究中,我们表明DEC1在胃癌患者不同背景和肿瘤组织的六种胃癌细胞系中频繁表达。还证实了DEC1表达与STAT3表达的显着关联。这些发现表明DEC1与胃癌密切相关。它可能通过STAT3信号通路在肿瘤发展中发挥作用。

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