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首页> 外文会议>10th World Multi-Conference on Systemics, Cybernetics and Informatics(WMSCI 2006) Jointly with the 12th International Conference on Information Systems Analysis and Synthesis(ISAS 2006) vol.2 >Combining Peripheral-Surgical (Tenotomy) with either Central-Pharmacological (Memantine) or other Peripheral-Surgical (Anderson) Therapies to Damp Acquired Pendular or Downbeat Nystagmus and Oscillopsia
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Combining Peripheral-Surgical (Tenotomy) with either Central-Pharmacological (Memantine) or other Peripheral-Surgical (Anderson) Therapies to Damp Acquired Pendular or Downbeat Nystagmus and Oscillopsia

机译：将外围外科（端截切开术）与中央药理学（美金刚）或其他外围外科（安德森）疗法相结合，以抑制获得性的垂体性或震颤性眼球震颤和眼球震颤

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We report the results of our studies of the effects of tenotomy on two different types of acquired nystagmus, pendular (APN) and downbeat (DBN). Eye movements of two subjects, Case 1 with APN and Case 2 with DBN were recorded using infrared reflection, magnetic search coil, or high-speed digital video. The eXpanded Nystagmus Acuity Function (NAFX) quantified tenotomy-induced foveation changes in the nystagmus. Horizontal rectus muscle tenotomies of both eyes were combined with recessions to correct exotropia (Case 1) and to move the null region downward (Case 2); memantine was given following surgery (Case 1). Search-coils were used to record ocular motility before and after surgery and after memantine in Case 1; high-speed digital video was used in Case 2. Following surgery, APN decreased by -50%, NAFX increased by 34%, and Snellen visual acuity increased 100% to 0.25. Saccades were unaffected. Memantine further damped the APN 69%, increased the NAFX by 9%, and increased visual acuity 60% to 0.4. The cumulative effects were: APN reduced by 82%; NAFX increased by 46%; acuity increased by 220%; and oscillopsia reduced by 75%. Following surgery, DBN decreased by 46%, NAFX increased by 17% in primary position over the previous peak at 10° upgaze, and visual acuity increased by 25% to 1.0+. Four-muscle surgery (including tenotomy and reattachment) reduced APN, DBN, and oscillopsia and improved NAFX and visual acuity; memantine provided additional improvement in APN. Their synergistic effect suggests a dual-mode (surgery + drug) therapy for maximal effectiveness in APN.
机译：我们报告了我们的研究对两种不同类型的获得性眼球震颤，垂体性（APN）和垂体性（DBN）的影响的研究的结果。使用红外反射，磁性搜索线圈或高速数字视频记录了两名受试者的眼动，即APN的病例1和DBN的病例2。扩展的眼球震颤敏锐度函数（NAFX）定量了由眼球切开术引起的眼球震颤的中心凹变化。将两只眼睛的水平直肌切开术与凹陷相结合以矫正外斜视（案例1）并向下移动无效区域（案例2）；美金刚在手术后进行（病例1）。在病例1中，使用搜索线圈记录手术前后，美金刚之后的眼球运动；案例2中使用了高速数字视频。手术后，APN降低了-50％，NAFX升高了34％，Snellen视力提高了100％至0.25。扫荡不受影响。美金刚胺进一步抑制了69％的APN，使NAFX增加了9％，并将视力提高了60％至0.4。累积影响为：APN减少了82％； NAFX增加了46％；视力提高220％；和骨膜减少了75％。手术后，DBN下降了46％，NAFX的主要位置在10°向上注视时比之前的峰值增加了17％，视力增加了25％，达到1.0+。四臂外科手术（包括腱切开术和复位术）可减少APN，DBN和振荡神经，并改善NAFX和视敏度；美金刚改善了APN。它们的协同作用表明，双模式（手术+药物）治疗可最大程度地提高APN的疗效。

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