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首页> 外文会议>12th Symposium on Bioluminescence and Chemiluminescence, Apr 5-9, 2002, Robinson College, University of Cambridge, UK >PERIPHERAL AND LOCAL ANTIOXIDANT DEFENCE IN PERIODONTAL DISEASE AND HEALTH BY ENHANCED CHEMILUMINESCENCE
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PERIPHERAL AND LOCAL ANTIOXIDANT DEFENCE IN PERIODONTAL DISEASE AND HEALTH BY ENHANCED CHEMILUMINESCENCE

机译：增强化学发光法在牙周疾病和健康中的外周和局部抗氧化剂防御

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Inflammatory periodontal disease continues to be a major concern for dentists and patients. Indeed, over half of the subjects examined in the most recent UK Adult Dental Health survey had moderate periodontal disease on at least one tooth. Oxidative stress is thought to make a significant contribution to all inflammatory diseases, including periodontitis. Whilst the concept of host parasite interactions providing the primary aetiological influence still holds true an increasing body of evidence is now available to implicate oxidants, in particular reactive oxygen species (ROS), in the pathogenesis of periodontal tissue breakdown. In the oral cavity, both commensal and potentially pathogenic bacteria are separated from underlying host tissues by a unique epithelial barrier called junctional epithelium. Unfortunately, bacterial products may cause increased junctional epithelium permeability and damage the underlying connective tissue. Defence of this unique barrier is dependent upon gingival crevicular fluid (GCF; a plasma transudate containing components required for immune competence) and neutrophils. Phagocytosis of bacteria by neutrophils is accompanied by 'respiratory burst', involving a sudden increase in non-mitochondrial oxidative metabolism and the production of ROS. Although primarily an antibacterial killing mechanism, these cells when recruited in large numbers to the gingival crevice provide potential for local tissue damage. In periodontitis such tissue damage is thought to be amplified due to the presence of hyperreactive neutrophils able to produce enhanced levels of superoxide. Whilst evidence accumulates for the role of ROS in the pathogenesis of periodontal disease, there is little data on the capability of the body to counteract such damage. Antioxidants are able to scavenge or prevent formation of these reactive species and may provide novel future therapies. Our group has previously reported the development of an enhanced chemiluminescent assay for determining total antioxidant defence in biological fluids including GCF. This paper describes initial results from ongoing studies to determine whether differences in periodontal health are associated with local (GCF and saliva) and systemic (plasma) antioxidant capacity.
机译：炎性牙周疾病仍然是牙医和患者关注的主要问题。确实，在最近的英国成人牙齿健康调查中检查的受试者中，有超过一半的受试者的至少一颗牙齿患有中度牙周疾病。氧化应激被认为对包括牙周炎在内的所有炎性疾病均起重要作用。尽管提供主要病因的宿主寄生虫相互作用的概念仍然成立，但现在越来越多的证据表明在牙周组织分解的发病机理中涉及氧化剂，特别是活性氧（ROS）。在口腔中，共生细菌和潜在致病细菌都通过称为接合上皮的独特上皮屏障与下面的宿主组织分离。不幸的是，细菌产物可能会导致连接上皮的通透性增加，并损害下面的结缔组织。这种独特屏障的防御取决于牙龈沟液（GCF；包含免疫能力所需成分的血浆渗出液）和中性粒细胞。中性粒细胞吞噬细菌的过程伴随着“呼吸爆发”，涉及非线粒体氧化代谢的突然增加和ROS的产生。尽管这些细胞主要是一种抗菌杀伤机制，但是当大量募集到牙龈缝隙中时，这些细胞可能会造成局部组织损伤。在牙周炎中，这种组织损伤被认为是由于存在能够产生提高水平的超氧化物的高反应性中性粒细胞而被放大的。尽管有证据表明ROS在牙周疾病的发病机理中的作用，但关于身体抵抗这种损害的能力的数据很少。抗氧化剂能够清除或阻止这些反应性物质的形成，并可能提供新的未来疗法。我们的小组先前曾报道过一种增强型化学发光测定法的发展，该测定法可用于测定包括GCF在内的生物液体中的总抗氧化剂防御能力。本文介绍了正在进行的研究的初步结果，以确定牙周健康的差异是否与局部（GCF和唾液）和全身（血浆）的抗氧化能力有关。

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