A Hybrid Sponge of Poly(DL-Lactic-Co-Glycolic Acid), Collagen and Apatite

机译：聚（DL-乳酸-乙醇酸），胶原蛋白和磷灰石的混合海绵

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Biodegradable poly(DL-lactic-co-glycolic acid), collagen and apatite have been hybridized to prepare a three-dimensional porous scaffold for hard tissue engineering. Collagen microsponges were first nested in the pores of a PLGA sponge to prepare PLGA-collagen sponge. And then the surfaces of collagen microsponges were deposited with apatite particulates by alternate immersion of PLGA-collagen sponge in CaCl_2 and Na_2HPO_4 aqueous solutions to prepare the PLGA-colagenapatite hybrid sponge. Observation of the hybrid sponge by scanning electron microscopy showed that collagen microsponges with interconnected pore structures were formed in the pores of PLGA sponge and that the pore surfaces were also covered with collagen. The deposited apatite particulates were flake-like and became denser and grew larger with repeated alternate immersion cycles. Energy-dispersive spectroscopy analysis and X-ray diffraction demonstrated that the deposited particulates were hydroxyapatite.

机译：已经将可生物降解的聚（DL-乳酸-乙醇酸），胶原蛋白和磷灰石杂交，以制备用于硬组织工程的三维多孔支架。首先将胶原微海绵嵌套在PLGA海绵的孔中，以制备PLGA胶原海绵。然后通过将PLGA胶原海绵交替浸入CaCl_2和Na_2HPO_4水溶液中，使磷灰石微粒沉积在胶原微海绵表面，从而制备PLGA-colagenapatite杂化海绵。通过扫描电子显微镜观察混合海绵，发现在PLGA海绵的孔中形成具有互连的孔结构的胶原微海绵，并且孔表面也被胶原覆盖。沉积的磷灰石颗粒呈片状，随着反复交替的浸没循环，变得更致密并变得更大。能量分散光谱分析和X射线衍射表明，沉积的颗粒是羟基磷灰石。

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《13th International Symposium on Ceramics in Medicine and the Annual Meeting of the International Society for Ceramics in Medicine 22-26 November 2000 Bologna, Italy》|2000年|p.753-756|共4页
会议地点 Bologna(IT);Bologna(IT);Bologna(IT);Bologna(IT)
作者
Guoping Chen; Takashi Ushida; Tetsuya Tateishi;
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正文语种 eng
中图分类基础医学;
关键词
3-Dimensional scaffold; apatite; collagen; poly(DL-lactic-co-glycolic acid); tissue engineering;

机译：3维支架磷灰石;胶原;聚（DL-乳酸-乙醇酸）;组织工程;

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1. A Hybrid sponge of Poly(DL-Lactic-Co-Glycolic Acid), Collagen and Apatite [J] . Guoping Chen, Takashi Ushida, Tetsuya Tateishi Key Engineering Materials . 2001,第期

机译：聚（DL-乳酸-乙醇酸），胶原蛋白和磷灰石的混合海绵
2. Poly (DL-lactic-co-glycolic acid) sponge hybridized with collagen microsponges and deposited apatite particulates [J] . Guoping Chen, Takashi Ushida, Tetsuya Tateishi Journal of biomedical materials research. Part B, Applied biomaterials. . 2001,第1期

机译：聚（DL-乳酸-乙醇酸）海绵与胶原蛋白微海绵杂交并沉积了磷灰石颗粒
3. Preparation of Cylinder-Shaped Porous Sponges of Poly(L-Iactic acid), Poly(DL-lactic-co-glycolic acid), and Poly(epslion-caprolactone) [J] . Xiaoming He, Naoki Kawazoe, Guoping Chen BioMed research international . 2014,第7期

机译：聚（L-乳酸），聚（DL-乳酸-共-乙醇酸）和聚（ε-己内酯）的圆柱状多孔海绵的制备
4. A Hybrid Sponge of Poly(DL-Lactic-Co-Glycolic Acid), Collagen and Apatite [C] . Guoping Chen, Takashi Ushida, Tetsuya Tateishi International symposium on ceramics in medicine . 2001

机译：聚（DL-LACTIC-CO-乙醇酸），胶原和磷灰石的混合海绵
5. BIOCHEMICAL STUDY OF POLY-ALPHA-L-GLUTAMIC ACID. PART I: THE EFFECT OF CONFORMATION ON THE CHEMICAL, PEPSIN OR PRONASE HYDROLYSIS OF POLY-ALPHA-L-GLUTAMIC ACID. PART II: BIOLOGICAL PROPERTIES OF POLY-ALPHA-L- GLUTAMIC ACID AND ITS DERIVATIVES. PART III: A NEW CALCIUM REQUIREMENT FOR THE HYDROLYSIS OF POLY-ALPHA-L-GLUTAMIC ACID BY THE CULTURE FILTRATESFROM BACILLUS LICHINOFORMIS. [D] . WAGLE, SUDHAKAR SHANTARAM. 1965

机译：聚α-L-谷氨酸的生物化学研究。第一部分：构象对聚-α-L-谷氨酸酸的化学，胃蛋白酶或蛋白酶水解的影响。第二部分：聚α-L-谷氨酸及其衍生物的生物学特性。第三部分：新的钙要求，用于培养滤液中的嗜酸芽孢杆菌（BACILLUS LICHINOFORMIS）水解聚-α-L-谷氨酸。
6. Preparation of Cylinder-Shaped Porous Sponges of Poly(L-lactic acid) Poly(DL-lactic-co-glycolic acid) and Poly(ε-caprolactone) [O] . Xiaoming He, Naoki Kawazoe, Guoping Chen -1

机译：聚（L-乳酸）聚（DL-乳酸-共-乙醇酸）和聚（ε-己内酯）的圆柱状多孔海绵的制备
7. Transfer of collagen coating from porogen to scaffold : collagen coating within poly(dl-lactic-co-glycolic acid) scaffold [O] . Li J, Mak AFT 2007

机译：胶原蛋白涂层从致孔剂到支架的转移：聚（dl-乳酸-乙醇酸共聚物）支架中的胶原蛋白涂层

A Hybrid Sponge of Poly(DL-Lactic-Co-Glycolic Acid), Collagen and Apatite

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