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首页> 外文会议>17th international conference on biomagnetism advances in biomagnetism - Biomag2010 >Relating Motor Cortical Oscillations to Motor y-Aminobutyric Acid (GABA)
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Relating Motor Cortical Oscillations to Motor y-Aminobutyric Acid (GABA)

机译：将运动皮质振荡与运动γ-氨基丁酸（GABA）相关

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摘要

The human motor cortex exhibits characteristic beta (15 - 30 Hz) and gamma oscillations (60-90 Hz) in the context of transient finger movement tasks. The functional significance of these oscillations, such as post-movement beta rebound (PMBR) and movement-related gamma synchrony (MRGS), remain unclear. Considerable animal and human non-invasive studies suggest that the networks supporting these motor cortex oscillations depend critically on the inhibitory neurotransmitter y-Aminobutyric acid (GABA). However, a direct relation between MEG measured motor cortex oscillation power and frequency with resting GABA concentrations in adult human participants has not been demonstrated. In the present study, motor cortical responses were measured from 8 healthy adults participating in a cued button-press task using the right index finger. PMBR and MRGS measures were obtained using beamformer differential source localization. In particular, PMBR and MRGS measures were obtained from the time-frequency plots obtained from beamformer localized primary motor (MI) sources. For each participant, complimentary magnetic resonance spectroscopy (MRS) GABA measures from the motor hand knob of the left central sulcus were also obtained. GABA concentration was estimated as the ratio of the motor cortex GABA integral to a reference GABA phantom. A significant linear relation was observed between Ml GABA concentration and PMBR power (R2 = 0.42, p=0.04), with no such relation observed for GABA and PMBR frequency. Conversely, a significant correlation was observed between MI GABA concentration and MRGS frequency (R2 = 0.67, />=0.01), with no correlation observed between GABA concentration and MRGS power. Present findings support a role for GABA in the generation and modulation of endogenous motor cortex rhythmic activity.
机译：在短暂的手指运动任务中，人类运动皮层表现出特征性的β（15-30 Hz）和伽马振动（60-90 Hz）。这些振荡的功能意义，例如运动后的β反弹（PMBR）和运动相关的伽马同步（MRGS），仍不清楚。大量的动物和人类非侵入性研究表明，支持这些运动皮层振荡的网络主要取决于抑制性神经递质γ-氨基丁酸（GABA）。然而，尚未证明MEG测量的运动皮层振荡功率和频率与成年人类参与者静息GABA浓度之间的直接关系。在本研究中，从使用右手食指进行提示性按键操作的8位健康成年人中测量了运动皮层反应。 PMBR和MRGS措施是使用Beamformer差分源定位技术获得的。特别是，PMBR和MRGS度量是从从波束成形器本地化主电动机（MI）源获得的时频图获得的。对于每个参与者，还可以从左中央沟的马达手旋钮获得免费的磁共振波谱（MRS）GABA测量。 GABA浓度估计为运动皮层GABA积分与参考GABA体模的比率。在M1 GABA浓度和PMBR功率之间观察到显着的线性关系（R 2 ＝ 0.42，p ＝ 0.04），而对于GABA和PMBR频率没有观察到这种关系。相反，在MI GABA浓度和MRGS频率之间观察到显着相关性（R2 = 0.67，/> = 0.01），而在GABA浓度和MRGS功率之间没有相关性。目前的发现支持GABA在内源性运动皮层节律性活动的产生和调节中的作用。

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