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首页> 外文会议>18th International Symposium on Fine Chemistry and Functional Polymers,4th IUPAC International Symposium on Novel Materials and Their Synthesis(第18届国际精细化学和功能高分子学术讨论会暨第四届IUPAC 国际新型材料及其制备学术讨论会） >Study on the Synthesis and Property of Narrow Distribution Low Polymerization Degree Chitosan with Gd-DTPA MRI Complexses
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Study on the Synthesis and Property of Narrow Distribution Low Polymerization Degree Chitosan with Gd-DTPA MRI Complexses

机译：Gd-DTPA MRI配合物窄分布低聚度壳聚糖的合成及性能研究

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Gd-DTPA (Magnevist,1) is a clinical MRI contrast agent,with an excellent magnetic property and good stability.However, the recently study revealed that 1 can act as a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis, and some countries have been stopped clinical use.It is a new tactic how to keep the excellent property and avoid renal disease,some tentative maneuvers have been explored,such as linking 1 with feasible polysaccharide and protein as well as enwrapped with polymer.Here we report that 1 derivative compounds with series narrow distribution chitooligosaecharides (CTSx-Gd-DTPA) and glucosamine (GLU-Gd-DTPA,2),using 1 as control.The magnetic properties were tasted on NMI20-Analyst(NMR Analyzer with Imaging,22 MHz,Shanghai Niumag Corp.),found DP=8 (CTS8-Gd-DTPA,3) with the best magnetic property,brief introduced as below:
机译：Gd-DTPA（Magnevist，1）是一种临床MRI造影剂，具有出色的磁性能和良好的稳定性。然而，最近的研究表明1可以作为导致肾原性纤维化皮肤病和肾原性系统性纤维化发展的特定诱因，如何保持优异的特性并避免肾脏疾病是一种新的策略，已探索出一些尝试性的方法，例如将1与可行的多糖和蛋白质连接以及包裹聚合物。报告称有1种具有窄分布的壳寡糖（CTSx-Gd-DTPA）和氨基葡萄糖（GLU-Gd-DTPA，2）的衍生物化合物，以1为对照。在NMI20-Analyst（NMR成像分析仪，具有成像功能）上品尝了磁性MHz，上海Niumag公司），发现具有最佳磁性能的DP = 8（CTS8-Gd-DTPA，3），简要介绍如下：

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