• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>18th International Symposium on Fine Chemistry and Functional Polymers,4th IUPAC International Symposium on Novel Materials and Their Synthesis(第18届国际精细化学和功能高分子学术讨论会暨第四届IUPAC 国际新型材料及其制备学术讨论会） >Controlled Synthesis of Polylatides using Biogenic Creatinine Carboxylate Initiators
【24h】

Controlled Synthesis of Polylatides using Biogenic Creatinine Carboxylate Initiators

机译：使用生物型肌酐羧酸盐引发剂可控地合成聚酰亚胺

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

1.Introduction In recent years the design and tailoring of biocompatible and biodegradable polymers have attracted considerable attention due to the increasingly demand of the pharmaeeutics and the biomedical science for bioresorbable materials. Polylactides (PLAs), homo-or eopolymers derived from lactides (LA) and glycolide, have found significant biomedical applications as resorhable sutures, drug-delivery carriers, artificial materials for tissue reconstruction and so forth. PLAs are prepared predominantly through ring-opening polymerization (ROP) of the corresponding cyclic esters. Stannous octoate Sn(Oct)2 is a widely and commercially used catalyst. The tin(Ⅱ) catalyst shows high catalytic efficiency in general, however its cytotoxicity has recently aroused increasingly deep concern about the biosafety of materials synthesized with it and use for man-purpose. Seeking tin-free catalysts of highly biosafety is a new challenge in this field. The design of metal-free organic initiators to realize the controlled synthesis of biodegradable polymers have recently attracted considerable interest and attention. Biodegradable polymers used for man-purse should be free of metals. Our work has focused on the design of guanidine-based initiators for the controlled synthesis of biodegradable polymers[1,2]. Guanidine is non-toxic organic base. Creatinine (CR) is a guanidine derivative participates in the human metabolism. Recently we synthesized two ereatinine carboxylates, I.e. Creatinine acetate (CRA) and ereatinine glycolate (CRG), and found that the two biogenic organic compounds effectively initiate the living ROP of lactides (Scheme 1).
机译：1引言近年来，由于药物和生物医学对生物可吸收材料的需求日益增长，生物相容性和生物可降解聚合物的设计和定制引起了人们的广泛关注。聚丙交酯（PLA）是源自丙交酯（LA）和乙交酯的均聚物或共聚体，已发现了重要的生物医学应用，如可缝线，药物输送载体，用于组织重建的人造材料等。主要通过相应环酯的开环聚合（ROP）制备PLA。辛酸亚锡Sn（Oct）2是广泛使用的商业催化剂。锡（Ⅱ）催化剂总体上显示出较高的催化效率，然而，其细胞毒性最近引起了人们对其与之合成并用于人为用途的材料的生物安全性的日益关注。寻求具有高度生物安全性的无锡催化剂是该领域的新挑战。用于实现可生物降解的聚合物的受控合成的无金属有机引发剂的设计近来引起了相当大的兴趣和关注。用于人钱包的可生物降解的聚合物应不含金属。我们的工作集中在基于胍的引发剂的设计上，该引发剂用于可生物降解的聚合物的受控合成[1,2]。胍是无毒的有机碱。肌酐（CR）是一种胍衍生物，参与人体代谢。最近，我们合成了两种Ereatinine羧酸盐，即乙酸肌酐（CRA）和甘氨酸肾上腺素（CRG），发现这两种生物有机化合物有效地引发了丙交酯的活性ROP（方案1）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号