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New supramolecular system binding to nucleic acids

机译:新的超分子系统与核酸结合

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Abstract: The potential of some novel dansylamide derivatives to complex with polynucleotides in aqueous solution has been investigated primarily by absorption, circular dichroism and fluorescence spectroscopy. The results indicate that these spectroscopies are strongly affected upon complexation, which may be contributed to the stacking interactions of the aromatic units, specific electronic interaction, and/or conformational changes of host-guest system. Besides, the nanostructural images of the complexes by atomic force microscopy also provide fresh direct evidence for the relationship between the structures of supramolecules and the relative conformational changes of nucleic acids.!7
机译:摘要:主要通过吸收,圆二色性和荧光光谱研究了一些新型丹磺酰胺衍生物与水溶液中的多核苷酸复合的潜力。结果表明,这些光谱学对络合有很大影响,这可能有助于芳香单元的堆积相互作用,特定的电子相互作用和/或主体-客体系统的构象变化。此外,通过原子力显微镜对复合物的纳米结构图像也为超分子的结构与核酸的相对构象变化之间的关系提供了新的直接证据。7

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