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首页> 外文会议>1999 International Conference on Biomedical Optics >Light-induced fluorescence endoscopy (LIFE) imaging system for early cancer detection
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Light-induced fluorescence endoscopy (LIFE) imaging system for early cancer detection

机译：光诱导荧光内窥镜（LIFE）成像系统用于早期癌症检测

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Abstract: This paper summarizes our experiences on the development of a Light Induced Fluorescence Endoscopy (LIFE) imaging system for early cancer detection in the respiratory and gastrointestinal tract. The system utilizes tissue autofluorescence to provide real time video imaging of the examined organ. No exogenous fluorescent tumor markers are needed. It is used by a physician in adjunct to conventional white-light endoscopy. Suspicious areas are identified in pseudo color to guide biopsy. A multi-center clinical trial has demonstrated that in the lung, the relative sensitivity of white-light imaging $PLU LIFE imaging vs. white-light imaging alone was 6.3 for intraepithelial neoplastic lesion detection and 2.71 when invasive carcinomas were also included. The following issues will be discussed: (1) spectroscopy study design for imaging system development; (2) architecture of the imaging systems; (3) different imaging modalities (white-light imaging, dual channel fluorescence imaging, and combined fluorescence/reflectance imaging); and (4) clinical applications.!56
机译：摘要：本文总结了我们在光诱导荧光内窥镜（LIFE）成像系统的开发方面的经验，该系统可用于呼吸道和胃肠道的早期癌症检测。该系统利用组织自发荧光来提供所检查器官的实时视频成像。不需要外源性荧光肿瘤标记物。由医师在常规白光内窥镜检查的辅助下使用。以伪彩色识别可疑区域，以指导活检。一项多中心临床试验表明，在肺中，上皮内肿瘤病变检测的白光成像（$ PLU LIFE成像）与单独白光成像的相对灵敏度分别为6.3和2.71（包括浸润性癌）。将讨论以下问题：（1）用于成像系统开发的光谱学研究设计； （2）成像系统的体系结构； （3）不同的成像方式（白光成像，双通道荧光成像和组合的荧光/反射成像）；和（4）临床应用。56

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