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首页> 外文会议>2002 International Conference on Process Modeling in Powder Metallurgy amp; Particulate Materials Oct 28-29, 2002 Newport Beach, California >DENSITY DISTRIBUTIONS IN PHARMACEUTICAL TABLETS: EXPERIMENTS AND MODELLING
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DENSITY DISTRIBUTIONS IN PHARMACEUTICAL TABLETS: EXPERIMENTS AND MODELLING

机译：药品平板电脑中的密度分布：实验和建模

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摘要

The relative density distribution in pharmaceutical tablets is important because it often affects the mechanical properties and dissolution characteristics. The compaction behavior of microcrystalline cellulose lubricated with magnesium stearate was investigated experimentally using a die press instrumented with axial load cells, axial displacement transducers and radial pressure sensors. Flat punches and punches having various curvatures, typical to those employed in industrial tablet compaction were used. Three material models (Gurson, Cam-Clay and Drucker-Prager) were calibrated based on die compaction experiments, uniaxial compression and diametrical compression. The friction behavior between powder and die wall has also been characterized experimentally. The evolution of the elastic and plastic model parameters during compaction was determined as a function of the relative density of the material. Finite element based simulations were carried out to investigate the effect of different punch curvatures on the density distribution within the tablets. Preliminary results on the density distribution were obtained using X ray microtomography.
机译：药物片剂中的相对密度分布很重要，因为它通常会影响机械性能和溶解特性。使用配备轴向载荷传感器，轴向位移传感器和径向压力传感器的模压机，对用硬脂酸镁润滑的微晶纤维素的压实行为进行了实验研究。使用平冲头和具有各种曲率的冲头，这些压头通常是工业压片中所采用的那些。基于压模实验，单轴压缩和径向压缩，对三种材料模型（Gurson，Cam-Clay和Drucker-Prager）进行了校准。粉末和模具壁之间的摩擦行为也已通过实验表征。确定压实过程中的弹性和塑性模型参数随材料相对密度的变化。进行了基于有限元的模拟，以研究不同冲头曲率对片剂内密度分布的影响。使用X射线显微断层摄影术获得了密度分布的初步结果。

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