Vibrational spectroscopic analysis of theophylline in a pharmaceutical granulation process using near-, mid- and far-infrared/terahertz spectroscopy

机译：使用近，中和远红外/太赫兹光谱在药物制粒过程中对茶碱进行振动光谱分析

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Vibrational spectroscopic analysis of theophylline in a wet granulation process was performed. An anhydride was converted to a monohydrate during the granulation and a dehydration of monohydrate progressed during the drying process. A C-N stretching would be affected by an interaction between theophylline and a binder under a wet granulation process.

机译：在湿法制粒过程中对茶碱进行了振动光谱分析。在制粒过程中，酸酐转化为一水合物，在干燥过程中一水合物脱水。在湿法制粒过程中，茶碱与粘合剂之间的相互作用会影响C-N的拉伸。

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来源
《International Conference on Infrared, Millimeter, and Terahertz Waves;IRMMW-THz 2012》|2012年|p.1- 2|共2页
会议地点 Wollongong(AU);Wollongong(AU)
作者
Sakamoto Tomoaki; Sasaki Tetsuo; Nishizawa Jun-ichi; Katori Noriko; Hiyama Yukio; Okuda Haruhiro;
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作者单位

Division of Drugs, National Institute of Health Sciences, Tokyo 158-8501, Japan;

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原文格式 PDF
正文语种 eng
中图分类无线电设备、电信设备;无线电设备、电信设备;
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1. Coupling of framework modes and adsorbate vibrations for CO_2 molecularly adsorbed on alkali ZSM-5 zeolites: Mid- and far-infrared spectroscopy and ab initio modeling [J] . E. Garrone, B. Bonelli, C. Lamberti, The Journal of Chemical Physics . 2002,第22期

机译：分子吸附在碱性ZSM-5沸石上的CO_2的构架模式和吸附物振动的耦合：中红外光谱和从头算模型
2. A Comparative Approach to Screen the Capability of Raman and Infrared (Mid- and Near-) Spectroscopy for Quantification of Low-Active Pharmaceutical Ingredient Content Solid Dosage Forms: The Case of Alprazolam [J] . Applied Spectroscopy: Society for Applied Spectroscopy . 2020,第6期

机译：筛选拉曼和红外（中近）光谱能力筛选低活性药物成分含量固体剂型的比较方法：Alprazolam的情况
3. Single crystal growth and polarization absorption spectroscopy of theophylline anhydrous for terahertz vibrational mode assignment [J] . Sasaki Tetsuo, Kambara Ohki, Sakamoto Tomoaki, Vibrational Spectroscopy: An International Journal devoted to Applications of Infrared and Raman Spectroscopy . 2016,第Null期

机译：太赫兹振动模式分配茶碱无水的单晶生长和偏振吸收光谱
4. Vibrational spectroscopic analysis of theophylline in a pharmaceutical granulation process using near-, mid- and far-infrared/terahertz spectroscopy [C] . Sakamoto Tomoaki, Sasaki Tetsuo, Nishizawa Jun-ichi, International Conference on Infrared,Millimeter and Terahertz Waves . 2012

机译：附近，中线和太赫兹光谱法的药物造粒过程中茶球线的振动光谱分析
5. On Ultrafast Time-Domain TeraHertz Spectroscopy in the Condensed Phase: Linear Spectroscopic Measurements of Hydrogen-Bond Dynamics of Astrochemical Ice Analogs and Nonlinear TeraHertz Kerr Effect Measurements of Vibrational Quantum Beats [D] . Allodi, Marco A. 2015

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6. Pharmaceutical Cocrystal Formation of Pyrazinamide with 3-Hydroxybenzoic Acid: A Terahertz and Raman Vibrational Spectroscopies Study [O] . Qiqi Wang, Jiadan Xue, Zhi Hong, 2019

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机译：关于凝聚相中的超快时域TeraHertz光谱：光化学冰类似物的氢键动力学的线性光谱测量和振动量子节拍的非线性TeraHertz Kerr效应测量

Vibrational spectroscopic analysis of theophylline in a pharmaceutical granulation process using near-, mid- and far-infrared/terahertz spectroscopy

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