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首页> 外文会议>BMEI 2012;International Conference on Biomedical Engineering and Informatics >Design, fabrication and detection of an integration micorfluidic chip
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Design, fabrication and detection of an integration micorfluidic chip

机译：集成微流控芯片的设计，制造和检测

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摘要

In this work, an integrated microfluidic chip with a multi-layer structure was designed, fabricated and detected for blood plasma isolation, mixing and immunoassays. Plasma was continuously separated from whole blood based on crossflow filtration principle by using a filter membrane. Then the isolated plasma and reagents were mixed in a crooked microchannel with shrunk structures and expanded structures in turns. Finally, immunoassays were implemented by the fluorescence detection technology. Under the optimal condition, the detected range of human IgG is 0.5∼5 μg/mL with a correlation coefficient of 0.9788. The integrated microfluidic chip has several advantages of lower cost, lower reagent and sample consumption, less analytical time and also disposability, which enables on-site detection for point-of-care clinical testing.
机译：在这项工作中，设计，制造并检测了具有多层结构的集成微流控芯片，用于血浆分离，混合和免疫测定。使用滤膜，根据错流过滤原理，连续从全血中分离血浆。然后将分离的血浆和试剂在弯曲的微通道中混合，该微通道依次具有收缩结构和扩展结构。最后，通过荧光检测技术进行免疫测定。在最佳条件下，人IgG的检测范围为0.5〜5μg/ mL，相关系数为0.9788。集成的微流控芯片具有以下优势：成本更低，试剂和样品消耗更少，分析时间更少以及可处理性更高，从而可以在现场进行即时检测以进行即时临床检测。

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