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Verification of Compartmental Epidemiological Models Using Metamorphic Testing, Model Checking and Visual Analytics

机译:使用变质测试,模型检查和可视化分析验证区室流行病学模型

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Compartmental models in epidemiology are widely used as a means to model disease spread mechanisms and understand how one can best control the disease in case an outbreak of a widespread epidemic occurs. However, a significant challenge within the community is in the development of approaches that can be used to rigorously verify and validate these models. In this paper, we present an approach to quantify and verify the behavioral properties of compartmental epidemiological models under several common modeling scenarios including: birth/death rates and multi-host/pathogen species. We build a workflow that uses metamorphic testing, novel visualization tools and model checking to gain insights into the functionality of compartmental epidemiological models. Our initial results indicate that metamorphic testing can be used to verify the implementation of these models and provide insights into special conditions where these mathematical models may fail. The visualization front-end allows the end-user to scan through a variety of parameters commonly used in these models to elucidate the conditions under which an epidemic can occur. Furthermore, specifying these models using a process algebra allows one to automatically construct behavioral properties that can be rigorously verified using model checking. Together, our approach allows for detecting implementation errors as well as handling conditions under which compartmental epidemiological models may fail to provide insights into disease spread dynamics.
机译:流行病学中的区室模型被广泛用作对疾病传播机制进行建模并了解在广泛流行病爆发时如何最好地控制疾病的一种方法。但是,社区内部的一项重大挑战是开发可用于严格验证和验证这些模型的方法。在本文中,我们提出一种方法来量化和验证在几种常见的建模方案下,隔室流行病学模型的行为特性,包括:出生/死亡率和多宿主/病原体物种。我们构建了一个使用变质测试,新颖的可视化工具和模型检查的工作流程,以深入了解部分流行病学模型的功能。我们的初步结果表明,可以使用变形测试来验证这些模型的实现,并提供对这些数学模型可能会失败的特殊条件的见解。可视化前端允许最终用户扫描这些模型中常用的各种参数,以阐明可能发生流行病的条件。此外,使用过程代数指定这些模型可以使人们自动构建可以使用模型检查进行严格验证的行为属性。总之,我们的方法可用于检测实施错误以及处理条件,在这种情况下,部分流行病学模型可能无法提供对疾病传播动态的洞察力。

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