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首页> 外文会议>2012 IEEE International Conference on Bioinformatics and Biomedicine. >The human imprintome vl.O: Over 120 imprinted genes in the human genome impose a major review on previous censuses
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The human imprintome vl.O: Over 120 imprinted genes in the human genome impose a major review on previous censuses

机译：人类烙印组v10：人类基因组中超过120个烙印基因对先前的普查进行了重大审查

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A relatively small number of human genes are marked with their parental origin and undergo a process termed "genomic imprinting", which, as a field of study, has grown rapidly in the last 20 years, with a growing figure of around 100 imprinted genes known in the mouse and approximately 120 in the human to comprise the updated whole set of human imprinted genes, the imprintome. Human imprintome is here analyzed by means of a reasonable, valid application of the Semantic Web and Linked Data approaches to a few structured datasets in order to provide a comprehensive collection of all known and predicted imprinted genes in the human genome. We have examined, compiled, structured and linked data to use them as a sharing resource for genome and epigenome interrogated studies regarding imprinted genes. Moreover, we offer our datasets of structured, linked data as being the actual research outcome of this human imprintome analysis because as genomics become more and more data intensive, due to huge amounts of biological data, so does our needs for more structured data to be easier mined and shared. The resulting version of the Linked Human Imprintome is a project within Linked Open Data (LOD) initiative (http://lod-cloud.net/) through Data Hub (http://thedatahub.org/en/dataset/a-draft-version-of-the-linked-human-imprintome).
机译：相对较少数量的人类基因带有其亲本起源标记，并经历称为“基因组印迹”的过程，作为一个研究领域，在过去20年中发展迅速，已知的约100个印迹基因的数量在不断增长小鼠中大约有120个基因，而人类中大约有120个，组成了更新的整套人类印迹基因，即印迹基因组。这里通过合理，有效地将语义网和链接数据方法应用于少数结构化数据集来分析人类印迹，以提供人类基因组中所有已知和预测的印迹基因的全面收集。我们已经检查，编辑，结构化和链接数据，以将它们用作基因组和表观基因组研究中有关印迹基因的共享资源。此外，我们提供结构化，链接数据的数据集作为此人类印迹组学分析的实际研究成果，因为随着大量的生物学数据导致基因组学变得越来越数据密集，我们对结构化数据的需求也越来越大易于挖掘和共享。链接人类烙印程序的最终版本是通过数据中心（http://thedatahub.org/en/dataset/a-draft）在链接开放数据（LOD）计划（http://lod-cloud.net/）中的一个项目。链接的人类烙印版本）。

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