Influence of collagen fiber architecture on calcific aortic valve disease progression

机译：胶原纤维结构对钙化主动脉瓣疾病进展的影响

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To understand the causes and progression of calcific aortic valve disease (CAVD), several in vitro models were studied using non-invasive imaging techniques. Explanted rat aortic valve leaflets were placed in culture medium to induce calcium nodule formation and valve interstitial cells (VICs) cultured from explanted rat valve leaflets were placed on collagen polyacrylamide (PAAM) gels of varying stiffness. The Second Harmonic Generation (SHG) signal and two-photon excited fluorescence (TPEF) generated by the collagen and calcium nodules, respectively, demonstrated that collagen fiber organization decreases with disease progression. Finally, using confocal fluorescence imaging, we found that average nodule size increases with substrate stiffness.

机译：为了了解钙化主动脉瓣疾病（CAVD）的原因和进展，使用无创成像技术研究了几种体外模型。将移植的大鼠主动脉瓣小叶放置在培养基中以诱导钙结节的形成，将从移植的大鼠主动脉瓣小叶培养的瓣膜间质细胞（VIC）放置在不同刚度的胶原蛋白聚丙烯酰胺（PAAM）凝胶上。胶原和钙结节分别产生第二谐波产生（SHG）信号和双光子激发荧光（TPEF），表明胶原纤维组织随疾病进展而减少。最后，使用共聚焦荧光成像，我们发现平均结节尺寸随基材硬度而增加。

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来源
《2014 40th Annual Northeast Bioengineering Conference》|2014年|1-2|共2页
会议地点 Boston MA(US)
作者
Baugh L.; Hinds P.; Huggins G.; Georgakoudi I.; Black L.D.;
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作者单位

Dept. of Biomed. Eng., Tufts Univ., Medford, MA, USA;

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原文格式 PDF
正文语种 eng
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关键词
biomechanics; biomedical optical imaging; cardiovascular system; cellular biophysics; diseases; elastic constants; fluorescence; molecular biophysics; optical harmonic generation; polymer gels; proteins; two-photon spectra; SHG; average nodule size; calcific aortic valve disease progression; calcium nodule formation; collagen fiber architecture; collagen fiber organization; collagen polyacrylamide gels; confocal fluorescence imaging; culture medium; explanted rat aortic valve leaflets; noninvasive imaging techniques;

机译：生物力学;生物医学光学成像;心血管系统;细胞生物物理学;疾病;弹性常数;荧光;分子生物物理学;光学谐波产生;聚合物凝胶;蛋白质;双光子光谱; SHG;平均结节大小;钙化主动脉瓣疾病进展;钙化结节形成;胶原纤维结构;胶原纤维组织;胶原聚丙烯酰胺凝胶;共聚焦荧光成像;培养基;大鼠主动脉瓣小叶植入;无创成像技术;;

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专利

1. Layer-Specific Changes in Collagen Fiber Architecture in Calcific Aortic Valve Disease [J] . Hutson Heather N., Campagnola Paul, Masters Kristyn S. Cardiology . 2016,第2期

机译：钙化性主动脉瓣疾病中胶原纤维结构的特定层变化
2. Layer-Specific Changes in Collagen Fiber Architecture in Calcific Aortic Valve Disease [J] . Hutson Heather N., Campagnola Paul, Masters Kristyn S. Cardiology . 2016,第2期

机译：钙化性主动脉瓣疾病中胶原纤维结构的特定层变化
3. Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update. [J] . Rajamannan NM, Evans FJ, Aikawa E, Circulation: An Official Journal of the American Heart Association . 2011,第16期

机译：钙化性主动脉瓣疾病：不仅仅是退化过程：美国国家心肺血液研究所主动脉瓣狭窄工作组的研究回顾和议程。摘要：钙化性主动脉瓣疾病-2011年更新。
4. Statins in Calcific Aortic Valve Disease: From Bench to BedsideDesigning Clinical Trials in Aortic Valve Disease: From Bench to Bedside [C] . Rajamannan Nalini M. Moura Luis M. World Congress on Heart Disese-International Academy of Cardiology Annual Scientific Session 2010 . 2010

机译：钙化主动脉瓣病的他汀类药物：从长凳到主动脉瓣病的临床试验：从长凳到床边
5. Pathology of Calcific Aortic Valve Disease: The Role of Mechanical and Biochemical Stimuli in Modulating the Phenotype of and Calcification by Valvular Interstitial Cells [D] . Yip, Cindy Ying Yin 2010

机译：钙化性主动脉瓣疾病的病理学：机械和生化刺激在调节表皮间质细胞表型和钙化中的作用
6. Calcific Aortic Valve Disease Is Associated with Layer-Specific Alterations in Collagen Architecture [O] . Heather N. Hutson, Taylor Marohl, Matthew Anderson, -1

机译：钙化性主动脉瓣疾病与胶原蛋白结构中特定于层的改变有关
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Influence of collagen fiber architecture on calcific aortic valve disease progression

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