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首页> 外文会议>2014 40th Annual Northeast Bioengineering Conference >Characterizing gold nanoparticle interactions with model cell membranes
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Characterizing gold nanoparticle interactions with model cell membranes

机译：表征金纳米颗粒与模型细胞膜的相互作用

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摘要

Gold nanoparticles are at the forefront of technology advances and drug delivery applications; however, there is still little knowledge on their toxicity. Our studies use a Quartz Crystal Microbalance with Dissipation to measure nanoparticle-membrane interactions. This assay allows us to look at the changes these nanoparticles have on model biological membranes in terms of frequency and dissipation results. By applying mathematical models, we are able to obtain further insight through looking at the membrane's mass changes due to contact with nanoparticles. Specifically, we investigated the size dependence of these gold nanoparticles while suspended in water and natural organic matter. Our method allows us to examine nanoparticle toxicity and insertion mechanisms, which provides insight on safe drug delivery technique.
机译：金纳米颗粒处于技术进步和药物输送应用的最前沿。然而，对其毒性的了解还很少。我们的研究使用带耗散的石英晶体微天平来测量纳米颗粒与膜之间的相互作用。该测定法使我们能够从频率和耗散结果的角度研究这些纳米颗粒对模型生物膜的变化。通过应用数学模型，我们能够通过查看由于与纳米颗粒接触而引起的膜的质量变化来获得更多的见解。具体来说，我们研究了这些金纳米颗粒悬浮在水和天然有机物中时的尺寸依赖性。我们的方法使我们能够检查纳米颗粒的毒性和插入机制，从而为安全的药物输送技术提供了见识。

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