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首页> 外文会议>2014 40th Annual Northeast Bioengineering Conference >Clinical administration of LPS endotoxin show changes in heart rate variability are detected prior to changes in temperature
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Clinical administration of LPS endotoxin show changes in heart rate variability are detected prior to changes in temperature

机译：LPS内毒素的临床给药显示在温度变化之前已检测到心率变异性的变化

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摘要

Sepsis is a significant cause of hospital deaths, but early detection could save lives. Heart rate variability (HRV) is a measurement of the change in heart rate and may be useful as a marker for early detection of sepsis. In this study, E. coli endotoxin was administered to healthy human subjects and changes in temperature and HRV were monitored at 6 hours post administration. HRV features measured were pNN50 and multi-scale entropy (MSE). We modeled changes in baseline using a sigmoidal model with 3 variables to help quantify dynamics of HRV and temperature time series. Curves of HRV and temperature versus time demonstrated that changes in HRV features preceded changes in temperature. Our model fits indicate HRV changes both begin earlier and occur faster than temperature or heart rate. Our findings are consistent with other group findings that demonstrate changes in interbeat intervals can be detected earlier than other signs of systemic inflammation.
机译：败血症是医院死亡的重要原因，但及早发现可以挽救生命。心率变异性（HRV）是心率变化的量度，可用作早期检测败血症的标志物。在这项研究中，将大肠杆菌内毒素施用于健康的人类受试者，并在给药后6小时监测温度和HRV的变化。测量的HRV特征为pNN50和多尺度熵（MSE）。我们使用具有3个变量的S型模型对基线的变化进行建模，以帮助量化HRV和温度时间序列的动态。 HRV和温度与时间的关系曲线表明，HRV特征的变化先于温度变化。我们的模型拟合表明，HRV变化比温度或心率变化更早开始并且发生得更快。我们的发现与其他小组发现一致，这些发现表明心跳间隔的变化可比其他全身性炎症迹象更早被发现。

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