3D simulation of primary thrombus formation based on Level Set Methods

机译：基于水平集方法的一次血栓形成的3D模拟

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The simulation of thrombosis is a popular research topic recently. Since Level Set Methods have well developed in fluid flow simulation, this paper presents a 3D simulation of primary thrombus formation based on Level Set Methods. A hybrid model including a macroscale model and a microscale model is built to simulate the flow, adhesion, and aggregation of platelets. The macroscale model is based on Navier-Stokes equations and the microscale model is described as external force and viscosity increase of platelets. By this simulation we observe the process of primary thrombus formation and analyze the effect of Reynolds Number (Re) to the formation rate. The results show that the formation rate increases with Re rise and this phenomenon becomes significant when Re is larger than the normal average Re of vessels which is a threshold value.

机译：血栓形成的模拟是最近流行的研究主题。由于“水平集方法”在流体流动模拟中已得到很好的发展，因此本文将基于“水平集方法”介绍一次血栓形成的3D模拟。建立包括宏观模型和微观模型的混合模型，以模拟血小板的流动，粘附和聚集。宏观模型基于Navier-Stokes方程，微观模型被描述为血小板的外力和粘度增加。通过该模拟，我们观察了初级血栓形成的过程，并分析了雷诺数（Re）对形成速率的影响。结果表明，随Re的增加，地层形成速率增加，当Re大于正常的平均Re值（阈值）时，这种现象变得很明显。

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来源
《2014 IEEE Computing, Communications and IT Applications Conference》|2014年|266-270|共5页
会议地点 Beijing(CN)
作者
Chaoqing Ma; Ou-Bong Gwun; Seung-Han Jeong;
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作者单位

Div. of Comput. Sci. Eng., Chonbuk Nat. Univ., Jeonju, South Korea;

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原文格式 PDF
正文语种 eng
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关键词
Navier-Stokes equations; flow simulation; 3D simulation; Navier-Stokes equations; Reynolds number; level set methods; macroscale model; microscale model; primary thrombus formation; Biological system modeling; Blood; Computational modeling; Equations; Level set; Mathematical model; Viscosity; Level Set Methods; particle simulation; thrombus;

机译：Navier-Stokes方程;流动模拟; 3D模拟; Navier-Stokes方程;雷诺数;水平集方法;宏观模型;微观模型;一次血栓形成;生物系统建模;血液;计算模型;方程;水平集;数学模型;粘度;水平设定方法;颗粒模拟;血栓;;

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3D simulation of primary thrombus formation based on Level Set Methods

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