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首页> 外文会议>2016 IEEE Healthcare Innovation Point-Of-Care Technologies Conference >Surface enhanced Raman spectroscopy as a tool for rapid and inexpensive diagnosis and antibiotic susceptibility testing for urinary tract infections
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Surface enhanced Raman spectroscopy as a tool for rapid and inexpensive diagnosis and antibiotic susceptibility testing for urinary tract infections

机译：表面增强拉曼光谱作为快速廉价的诊断和尿道感染抗生素敏感性测试的工具

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摘要

Urinary Tract Infections (UTIs) are some of the most common bacterial diseases, especially in women, resulting in millions of hospital visits and a cost of 1.6 billion dollars every year in the US alone. Currently, diagnosis is performed with two sequential urine cultures, for species identification and antibiotic susceptibility testing, which require a total of 48 hrs. The limitations of the current scheme can be overcome by the development of a Surface Enhanced Raman Spectroscopy (SERS) based diagnostic. The proposed technology can: (i) identify the presence of bacteria (correctly quantifies the concentration and specifies the bacteurimic samples), (ii) classify the causative bacteria (~94% correct classification), and (iii) determine the sensitivity of the bacteria to various antibiotics (81-100% correct classification depending on the antibiotic). These results demonstrate that SERS can be used for complete, fast, accurate, and inexpensive POCT for urinary tract and other bacterial infections.
机译：尿路感染（UTIs）是一些最常见的细菌性疾病，尤其是在女性中，仅在美国每年就导致数百万的医院就诊和每年16亿美元的损失。目前，诊断是使用两个连续的尿液培养物进行的，用于物种鉴定和抗生素敏感性测试，总共需要48小时。当前方案的局限性可以通过开发基于表面增强拉曼光谱（SERS）的诊断技术来克服。所提出的技术可以：（i）识别细菌的存在（正确量化浓度并指定细菌尿样），（ii）对致病细菌进行分类（正确分类率约94％），以及（iii）确定细菌的敏感性各种抗生素（根据抗生素正确分类为81-100％）。这些结果表明，SERS可用于尿路和其他细菌感染的完整，快速，准确和廉价的POCT。

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