Modeling basal ganglia circuits with mass model equations

机译：用质量模型方程建模基底神经节回路

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In order to understand the cognitive processes, motor actions and the behavioral deficits and neurological disorders rising due to malfunctioning of the related neuronal structures, models at different levels are proposed in computational neuroscience. Models developed considering the nonlinear and distributed working principles of neural structures help to reconstruct the processes but are far away from giving an explicit understanding of the phenomena due to their complexity. However, it is not possible to understand these processes thoroughly with very simple models. To build a relation between these different levels of models and to build a mechanism for understanding these processes, in this work linear model approach is considered. Basal ganglia circuits which are effective in motor action initiation, decision making and action selection is considered and in order to guide through more complex computational models and to understand the working principle, a linear system approach is considered. Though the model proposed is very simple, it gives enough insight to understand the role of basal ganglia circuits and the model is able to show the role of dopamine on modulating the inputs from cortex.

机译：为了了解由于相关神经元结构失灵而引起的认知过程，运动行为，行为缺陷和神经系统疾病，在计算神经科学中提出了不同级别的模型。考虑到神经结构的非线性和分布式工作原理而开发的模型有助于重构过程，但由于其复杂性而无法提供对现象的明确理解。但是，用非常简单的模型不可能完全理解这些过程。为了在这些不同级别的模型之间建立关系并建立一种理解这些过程的机制，本文考虑了线性模型方法。考虑了在运动动作启动，决策和动作选择方面有效的基底神经节回路，并且为了指导更复杂的计算模型并理解工作原理，考虑了线性系统方法。尽管提出的模型非常简单，但是它提供了足够的洞察力来理解基底神经节回路的作用，并且该模型能够显示多巴胺在调节皮质输入中的作用。

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《2016 Medical Technologies National Congress》|2016年|1-4|共4页
会议地点 Antalya(TR)
作者
Rahmi Elibol; Neslihan Serap Şengör;
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作者单位

Elektronik ve Haberleşme Mühendisliği Bölümü, İstanbul Teknik Üniversitesi, İstanbul, Türkiye;

Elektronik ve Haberleşme Mühendisliği Bölümü, İstanbul Teknik Üniversitesi, İstanbul, Türkiye;

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正文语种 eng
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关键词
Dogs; Integrated circuit modeling; Computational modeling; Brain modeling; Mathematical model; Basal ganglia; Neuroscience;

机译：狗;集成电路模型;计算模型;脑模型;数学模型;基底神经节;神经科学;

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专利

1. Modeling facilitation and inhibition of competing motor programs in basal ganglia subthalamic nucleus-pallidal circuits [J] . Leonid L. Rubchinsky, Nancy Kopell, Karen A. Sigvardt Proceedings of the National Academy of Sciences of the United States of America . 2003,第24期

机译：模拟促进和抑制基底节丘脑丘脑底-下丘脑回路中竞争性运动程序
2. Modeling parkinsonian circuitry and the DBS electrode. II. Evaluation of a computer simulation model of the basal ganglia with and without subthalamic nucleus stimulation. [J] . Shils JL, Mei LZ, Arle JE Stereotactic and Functional Neurosurgery: Official Journal of the World Society for Stereotactic and Functional Neurosurgery . 2008,第1期

机译：对帕金森电路和DBS电极建模。二。带有和不带有丘脑底核刺激的基底神经节的计算机模拟模型的评估。
3. Modeling of waveguide circuits based on generalized transmission line equations and impedance/admittance transformation concept [J] . Reinhold Pregla, Stefan F. Helfert International journal of applied electromagnetics and mechanics . 2003,第1a3期

机译：基于广义传输线方程和阻抗/导纳变换概念的波导电路建模
4. Modeling basal ganglia circuits with mass model equations [C] . Rahmi Elibol, Neslihan Serap ?eng?r Medical Technologies National Congress . 2016

机译：用质量模型方程建模基底神经节电路
5. Modeling and design of DC power bus interconnects, segmentation, and signal via transitions in multi-layer printed circuit boards using FDTD and a mixed-potential integral equation approach with circuit extraction. [D] . Cui, Wei. 2001

机译：使用FDTD和带有电路提取的混合电位积分方程方法，对多层印刷电路板中的DC电源总线互连，分段和信号过渡进行建模和设计。
6. Modeling facilitation and inhibition of competing motor programs in basal ganglia subthalamic nucleus–pallidal circuits [O] . Leonid L. Rubchinsky, Nancy Kopell, Karen A. Sigvardt 2003

机译：模拟促进和抑制基底神经节丘脑下丘脑核-苍白回路的竞争性运动程序
7. This article presents a new numerical model describing the behaviour of a thermally thick wood sample exposed to high solar heat flux (above 1 MW/m2). A preliminary study based on dimensionless numbers is used to classify the problem and support model building assumptions. Then, a model based on mass, momentum and energy balance equations is proposed. These equations are coupled with liquid-vapour drying model and pseudo species biomass degradation model. By comparing to a former experimental study, preliminary results have shown that these equations are not enough to accurately predict biomass behaviour under high solar heat flux. Indeed, a char layer acting as radiative shield forms on the sample exposed surface. In addition to this classical set of equations, it is mandatory to take into account radiation penetration into the medium. Furthermore, as biomass contains water, medium deformation consecutively to char steam gasification must also be implemented. Finally, with the addition of these two strategies, the model is able to properly capture the degradation of biomass when exposed to high radiative heat flux over a range of sample initial moisture content. Additional insights of biomass behaviour under high solar heat flux were also derived. Drying, pyrolysis and gasification fronts are present at the same time inside of the sample. The coexistence of these three thermochemical fronts leads to char gasification by the steam produced from drying of the sample, which it is the main phenomenon behind medium ablation. [O] . Pozzobon, Victor, Salvador, Sylvain, Bézian, Jean Jacques 2018

机译：本文提供了一个新的数值模型，该模型描述了暴露于高太阳热通量（高于1 / MW / m2）的热厚木材样品的行为。基于无量纲数的初步研究用于对问题进行分类并支持模型构建假设。然后，提出了一种基于质量，动量和能量平衡方程的模型。这些方程式与液体蒸汽干燥模型和假物种生物质降解模型耦合。通过与以前的实验研究进行比较，初步结果表明，这些方程不足以准确预测高太阳热通量下的生物量行为。的确，在样品暴露的表面上形成了充当辐射屏蔽层的炭层。除了这套经典的方程式之外，还必须考虑到辐射向介质的渗透。此外，由于生物质中含有水，因此还必须在炭蒸气汽化后进行连续的介质变形。最后，通过添加这两种策略，该模型能够在一定范围的样品初始水分含量下暴露于高辐射热通量的情况下，正确捕获生物质的降解。还得出了在高太阳热通量下生物量行为的其他见解。样品内部同时存在干燥，热解和气化前沿。这三个热化学前沿的共存会导致样品干燥产生的蒸汽产生焦炭气化，这是介质烧蚀的主要现象。
8. Connectionist Modeling of Basal Ganglia Motor Circuitry [R] . Alexander, G. E. 1996

机译：基底神经节运动电路的连接模型

Modeling basal ganglia circuits with mass model equations

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