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首页> 外文会议>2018 IEEE 4th Middle East Conference on Biomedical Engineering >Measuring recto-anal Inhibitory reflex using functional lumen imaging probe: A pilot study
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Measuring recto-anal Inhibitory reflex using functional lumen imaging probe: A pilot study

机译：使用功能性管腔成像探头测量直肠肛门抑制反射的初步研究

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Faecal incontinence is a multi-factorial challenging problem. The maintenance of faecal continence relies on a complex voluntary and involuntary coordination between anal and colorectal activity. The aim of this study is to introduce a new method for measuring anal sphincter distensibility and function during voluntary manoeuvres like squeezing and straining as well as involuntary manoeuvres like recto-anal inhibitory reflex (RAIR) testing and slow rectal distension. A modified functional lumen imaging probe (FLIP) consisted of the rectal balloon to distend and measure the pressure in the rectum and the anal bag which contained 16 sensing electrode capable of measuring serial cross-sectional areas (CSA) of the anal bag. The CSAs were converted to functional images of the anal canal geometry. The bag pressure was also measured during anal distension. The probe was bench tested and the CSA measured by EndoFLIP system was calibrated. Four healthy volunteers (2 males/2 females) and one faecal incontinence patient were recruited for the studies. The probe was inserted in the anal canal with 2cm of the anal bag located outside the anal verge. The anal bag was distended from 0ml to 50ml, and then the volunteers were asked to rest, squeeze and strain voluntarily at specific step volumes in the anal bag. RAIR and slow rectal distension tests were also measured at three step distensions in the anal bag. The results showed that the distal end relaxed more than the proximal end during ramp distension. The anal canal length decreased as a linear function of the distending bag volume. The functional images measured during manoeuvres showed the contraction of the proximal part of the anal canal by 12mmn2nduring squeezing and the relaxation by 10mmn2nduring straining test. During the RAIR test, the distal part of the anal canal relaxed by 14mmn2n. The distal part of the anal canal relaxed by 20mmn2nand the proximal part contracted by 10mmn2nduring the slow rectal distension which mimics the defecation. In conclusion the modified EndoFLIP was capable of describing the anal distensibility and sphincteric function for different manoeuvres.
机译：粪便失禁是一个多方面的挑战性问题。粪便节制的维持依赖于肛门和结直肠活动之间复杂的自愿和非自愿协调。这项研究的目的是介绍一种新方法，用于测量自愿性操作（如挤压和拉伤）以及非自愿性操作（如直肠肛门抑制反射（RAIR）测试和直肠缓慢扩张）过程中肛门括约肌的可扩张性和功能。一种改进的功能性管腔成像探头（FLIP）由直肠球囊组成，用于扩张并测量直肠中的压力；肛门袋包含16个能够测量肛门袋的连续横截面积（CSA）的传感电极。 CSA被转换为肛管几何形状的功能图像。在肛门扩张期间还测量了袋压力。对该探针进行了台式测试，并对通过EndoFLIP系统测得的CSA进行了校准。招募了四名健康志愿者（2名男性/ 2名女性）和1名大便失禁患者。将探针插入肛管，肛门边缘外侧有2cm的肛门袋。将肛门袋从0ml扩大到50ml，然后要求志愿者在肛门袋中以特定的步长自愿休息，挤压和拉紧。还对肛门袋中的三步扩张进行了RAIR和直肠缓慢扩张测试。结果显示，在斜坡扩张期间，远端比近端更放松。肛管长度随袋扩张容积的线性关系而减小。在操作过程中测得的功能图像显示肛门管近端部分收缩了12mmn 2 通过10mmn受到挤压和放松 2 耐力测试。在RAIR测试期间，肛管的远端部分松弛了14mmn 2 n。肛门管远端放松20mmn 2 n，近端部分收缩10mmn 2 进行缓慢的直肠扩张，模仿排便。总之，改良的EndoFLIP能够描述不同动作的肛门扩张性和括约肌功能。

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