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首页> 外文会议>2018 International Conference on Advanced Communication Technologies and Networking >Suppression of calculi growth based on the mathematical model of the pathogenesis of urolithiasis
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Suppression of calculi growth based on the mathematical model of the pathogenesis of urolithiasis

机译：基于尿路结石发病机理数学模型的结石生长抑制

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So far various studies for the cause of the onset of urolithiasis has been made and the factors influencing the pathogenesis has been almost clear. On the other hand, though the understanding of individual factor influencing the pathogenesis has progressed biologically and clinically, theoretical study of the integrated dynamics leading to the calculus of urolithiasis through the crystal growth and aggregation from the crystal nucleation using a mathematical model has not been made yet. Then I derived the mathematical model of the process leading to the onset of urolithiasis so as to clarify how a variety of factors affecting urolithiasis influence the pathogenesis quantitatively. In the mathematical model, the process leading to the onset of urolithiasis is divided into the following three processes. (1) formation of crystal nuclei. (2) formation of calculi by growth of crystal nuclei. (3) bonding of calculi to urinary tract cells and growth of calculi. In addition, the parameters of the volume of the urinary tract, the flow rate of urine etc. are introduced to represent the characteristics of the urinary tract. As a result, for instance, in case of calcium oxalate calculi, the conditions that the calculus does not grow were shown analytically and numerically. And the dependence of the growth of the calculus on the volume of the urinary tract or the flow rate of urine was also clarified analytically and numerically. Then, based on the analysis of this mathematical model, we propose specific solutions in clinical.
机译：迄今为止，已经对尿路结石的发病原因进行了各种研究，并且几乎完全清楚了影响发病机理的因素。另一方面，尽管对影响发病机理的个体因素的理解已经在生物学和临床上取得了进展，但尚未进行通过数学模型通过晶体生长和晶体成核聚集而导致尿石症结石的综合动力学的理论研究。然而。然后，我导出了导致尿石症发作的过程的数学模型，以阐明影响尿石症的各种因素如何定量地影响发病机理。在数学模型中，导致尿石症发作的过程分为以下三个过程。 （1）形成晶核。 （2）通过晶核的生长形成结石。 （3）结石与尿道细胞的结合和结石的生长。另外，引入尿道容积，尿流率等参数来代表尿道的特征。结果，例如，在草酸钙结石的情况下，通过分析和数字显示了牙结石不生长的条件。而且，还通过分析和数字阐明了结石的生长对尿路体积或尿流率的依赖性。然后，基于对该数学模型的分析，我们提出了临床上的具体解决方案。

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