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首页> 外文会议>23rd European conference on biomaterials 2010 >Surface treatment improving primary human renal proximal tubule cell performance on polymeric membranes for applications in bioartificial kidneys
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Surface treatment improving primary human renal proximal tubule cell performance on polymeric membranes for applications in bioartificial kidneys

机译：表面处理可改善聚合物膜上人原发性肾近端小管细胞的性能，以用于生物人工肾

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摘要

Purpose of the study: The kidney plays a critical role in the body, by not only filtering the blood and eliminating waste products, but also balancing levels of electrolytes, controlling blood pressure, and stimulating the production of red blood cells. Among 26 different types of kidney cells, renal proximal tubule epithelial cells are the most important one as they are involved in blood clearance and reabsorption of essential metabolites, water, proteins, and advanced glycation end-products after glomerular filtration. To engineer a bioartificial kidney, primary human proximal tubular cells (HPTCs) need to be included as they are the most clinically relevant ones. However, studies regarding biomaterials interaction with HPTCs are very limited. Also, conventional hemodialysis membranes, such as cellulose and polysulfone, are not suitable for supporting the growth of HPTCs. In this study, we investigated the possibility of using surface treatment to enhance the renal cell performance on polymeric membranes so that it could be used as a scaffolding material for bioartificial kidney device.
机译：研究目的：肾脏不仅在过滤血液和消除废物中起着至关重要的作用，而且还可以平衡电解质水平，控制血压并刺激红血球的生成。在26种不同类型的肾细胞中，肾近端肾小管上皮细胞是最重要的一种，因为它们参与血液清除以及肾小球滤过后必需代谢产物，水，蛋白质和高级糖化终产物的重吸收。要改造生物人工肾，必须包括原发性人类近端肾小管细胞（HPTC），因为它们是临床上最相关的细胞。但是，有关生物材料与HPTC相互作用的研究非常有限。同样，常规的血液透析膜，例如纤维素和聚砜，也不适合支持HPTC的生长。在这项研究中，我们研究了使用表面处理来增强聚合物膜上的肾细胞性能的可能性，以便可以将其用作生物人工肾装置的支架材料。

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  • 来源
  • 会议地点 Tampere(FI);Tampere(FI)
  • 作者

    Ming Ni; Jackie Y. Ying;

  • 作者单位

    Mohammed Shahrudin bin Ibrahim, Jeremy Teo, Farah Tasnim, Edwin Chow, Daniele Zink;

    Institute of Bioengineering and Nano techno logy, 31 Biopolis Way, The Nanos, Singapore 138669;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 TB347;
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