• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>26th European conference on biomaterials 2014 >Ex vivo osteo-chondral organ culture
【24h】

Ex vivo osteo-chondral organ culture

机译：离体骨软骨器官培养

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cutting edge bioreactor systems will improve the in vitro culture conditions and allow long term plug culture under more physiological cues up to 6 weeks. For this reason we need to give consideration to mechanotransduction. Regarding the limited diffusion of the MTT reagent into the core of the plugs the diffusion of nutrients and removal of waste products will be characterized in more detail by μCT and MRI. Data obtained from REM, uCT, MRI and experimental results of plug culture will be used as input for the developing of a mathematical model. The in silico model will allow the simulation of biochemical and biophysical processes within the plug and contribute a better understanding of the different processes in the defect healing as well as in nutrition supply to keep the explant culture vital. The establishment of the predictive 3D in vitro assay for (sub-) chondral implants requires the validation of the outcomes from our test system against in vivo models.
机译：先进的生物反应器系统将改善体外培养条件，并允许在长达6周的更多生理线索下进行长期的栓塞培养。因此，我们需要考虑机械转导。关于MTT试剂向塞子核心的有限扩散，将通过μCT和MRI更详细地描述养分的扩散和废物的去除。从REM，uCT，MRI和栓塞培养的实验结果获得的数据将用作开发数学模型的输入。硅计算机模型将允许模拟塞子内的生化和生物物理过程，并有助于更好地理解缺损愈合以及营养供应中的不同过程，以保持外植体培养至关重要。建立（亚）软骨植入物的预测性3D体外测定需要建立针对体内模型的测试系统的结果验证。

著录项

  • 来源
  • 会议地点 Liverpool(GB)
  • 作者

    Andrea Schwab; Jenny W Reboredo; Heike Walles;

  • 作者单位

    Tissue Engineering Regenerative Medicine, University Hospital Wuerzburg, Germany;

    Tissue Engineering Regenerative Medicine, University Hospital Wuerzburg, Germany;

    Tissue Engineering Regenerative Medicine, University Hospital Wuerzburg, Germany;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号