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首页> 外文会议>3rd international symposium on dairy cow nutrition and milk quality proceedings >Acetic acid activates the AMP-activatedproteinkinase signaling pathway to regulate lipid metabolism in bovine hepatocytes
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Acetic acid activates the AMP-activatedproteinkinase signaling pathway to regulate lipid metabolism in bovine hepatocytes

机译：乙酸激活AMP激活的蛋白激酶信号通路来调节牛肝细胞的脂质代谢

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摘要

Introduction Ruminal micro-organisms convert cellulose and starch to volatile fatty acids (VFAs).Acetic acid accounts for 70-75％ of VFAs.Acetic acid is mainly used for milk fat synthesis in dairy cows (Bergman,1990).In recent years,it has become evident that acetic acid can also act as a signaling molecule to regulate gene expression in the liver (Fushimi et al.,2006).AMP-activatedproteinkinase(AMPK) modulates hepatic lipid metabolism by regulating several lipid metabolism-related transcription factors such as peroxisome proliferator-activated receptor α (PPARα),sterol regulatory element-binding protein 1 c (SREBP-1 c),and carbohydrate responsive element-binding protein (ChREBP),all of which govern the expression of lipid metabolic enzymes (Bronner et al.,2004).
机译：简介瘤胃微生物将纤维素和淀粉转化为挥发性脂肪酸（VFA）。乙酸占VFA的70-75％。乙酸主要用于奶牛的乳脂合成（Bergman，1990）。乙酸也可以作为调节肝脏中基因表达的信号分子（Fushimi et al。，2006）。AMP激活的蛋白激酶（AMPK）通过调节一些脂质代谢相关的转录因子来调节肝脏的脂质代谢。作为过氧化物酶体增殖物激活受体α（PPARα），固醇调节元件结合蛋白1 c（SREBP-1 c）和碳水化合物反应元件结合蛋白（ChREBP），它们均控制脂质代谢酶的表达（Bronner等等人，2004）。

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  • 会议地点 Beijing(CN)
  • 作者

    X.W.Li; H.Chen; Y.Guan; X.Li; L.Lei; J.Liu; L.Yin; G.Liu; Z.Wang;

  • 作者单位

    College of Veterinary Medicine, Jilin University, 5333 Xi'an Road, Changchun, Jilin, 130062, China;

    College of Veterinary Medicine, Jilin University, 5333 Xi'an Road, Changchun, Jilin, 130062, China;

    College of Veterinary Medicine, Jilin University, 5333 Xi'an Road, Changchun, Jilin, 130062, China;

    College of Veterinary Medicine, Jilin University, 5333 Xi'an Road, Changchun, Jilin, 130062, China;

    College of Veterinary Medicine, Jilin University, 5333 Xi'an Road, Changchun, Jilin, 130062, China;

    College of Veterinary Medicine, Jilin University, 5333 Xi'an Road, Changchun, Jilin, 130062, China;

    College of Veterinary Medicine, Jilin University, 5333 Xi'an Road, Changchun, Jilin, 130062, China;

    College of Veterinary Medicine, Jilin University, 5333 Xi'an Road, Changchun, Jilin, 130062, China;

    College of Veterinary Medicine, Jilin University, 5333 Xi'an Road, Changchun, Jilin, 130062, China;

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