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首页> 外文会议>46th annual rocky mountain bioengineering symposium amp; 46th international ISA biomedical sciences instrumentation symposium 2009 >THE ROLE OF ESTROGEN, TESTOSTERONE, AND PARATHYROID HORMONES IN COMBINATION WITH CONVENTIONAL AND SUSTAINED ANTIOXIDANT TREATMENT ON LNCAP CELLS
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THE ROLE OF ESTROGEN, TESTOSTERONE, AND PARATHYROID HORMONES IN COMBINATION WITH CONVENTIONAL AND SUSTAINED ANTIOXIDANT TREATMENT ON LNCAP CELLS

机译：雌激素，睾丸激素和副甲状腺激素与常规和持续抗氧化剂治疗对LNCAP细胞的作用

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As men age, they will begin to experience numerous changes in their bodies and sometimes these changes are life threatening. Unfortunately, these alterations can result in prostate cancer which tends to be a major public health issue and a leading cause of cancer-related deaths in males (Greenlee et al., 2001). Androgens are metabolites of testosterone (TST), which are essential for maintenance of the normal morphology and function of the prostate gland. With advancing age, transpositions can result in reduced testosterone levels and alter the ratio between testosterone and the chief female hormone, estrogen (Harman 2005). Testosterone is the major circulating androgen and it plays a major role in the overall health and well-being of both sexes. Similarly, estrogen (EST) is equally important and has been shown to be a powerful antioxidant responsible for suppressing free radical-induced peroxidation chain reactions (Sugioka et al., 1987; Green et al., 1997). Parathyroid hormone (PTH) is also a significant hormone responsible for regulating the calcium and phosphate within the body. Research has been ongoing examining these hormones in specific conditions to determine then-effects (Bhasin 2003; Tanaka et al 2004; Young et al 2004). In this study, three antioxidants, epigallocatehin -3-gallate (EGCG), thymoqumone (TQ), and tannic acid (TA) were analyzed in combination with the above hormones to compare the effects of conventional and sustained administration of TST, EST, and PTH. Data of the study demonstrated that regardless of the route of administration cell growth was suppressed. Overall results revealed that route of administration played a significant role in disrupting prostate cancer growth.
机译：随着年龄的增长，他们将开始经历许多身体变化，有时这些变化会威胁生命。不幸的是，这些改变会导致前列腺癌，这往往是一个主要的公共卫生问题，也是男性因癌症而死亡的主要原因（Greenlee等，2001）。雄激素是睾丸激素（TST）的代谢产物，对于维持前列腺正常形态和功能至关重要。随着年龄的增长，转座会导致睾丸激素水平降低，并改变睾丸激素与主要女性激素雌激素之间的比例（Harman 2005）。睾丸激素是主要的循环雄激素，在男女双方的整体健康和福祉中起着重要作用。同样，雌激素（EST）同样重要，并且已被证明是一种强大的抗氧化剂，可抑制自由基诱导的过氧化链反应（Sugioka等，1987； Green等，1997）。甲状旁腺激素（PTH）也是一种重要的激素，负责调节体内的钙和磷酸盐。正在进行研究以特定条件检查这些激素以确定随后的效果（Bhasin 2003； Tanaka等2004； Young等2004）。在这项研究中，结合上述激素分析了三种抗氧化剂，表没食子儿茶素-3-没食子酸酯（EGCG），胸腺嘧啶酮（TQ）和单宁酸（TA），以比较常规和持续施用TST，EST和PTH。研究数据表明，无论给药途径如何，细胞生长均受到抑制。总体结果表明，给药途径在破坏前列腺癌生长中起着重要作用。

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