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首页> 外文会议>4th International Conference on Biomedical Engineering in Vietnam >Pharmacodynamics and Pharmacokinetics of Exendin-4 Orally Delivered via an Enteric Coated Capsule Containing Nanoparticle in Diabetic Rats
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Pharmacodynamics and Pharmacokinetics of Exendin-4 Orally Delivered via an Enteric Coated Capsule Containing Nanoparticle in Diabetic Rats

机译：通过含有纳米颗粒的肠溶衣胶囊口服给药的Exendin-4在糖尿病大鼠中的药效动力学和药代动力学

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摘要

An orally available exendin-4 formulation, using an enteric-coated capsule containing pH-sensitive NPs, was studied. In the in vivo dissolution study, it was found that the enteric-coated capsule remained intact while in the stomach; the capsule was completely dissolved in the proximal segment of the small intestine and the loaded contents were then released. Oral administration of the capsule containing exendin-4 loaded NPs showed a maximum plasma concentration at 5 h after treatment; the bioavailability, relative to its subcutaneous counterpart, was found to be 14.0 ± 1.8 %. The absorbed exendin-4 could then stimulate the insulin secretion and provide a prolonged glucose-lowering effect. The aforementioned results suggest that the orally available exendin-4 formulation developed warrants further exploration as a potential therapy for diabetic patients.
机译：使用含有pH敏感NP的肠溶胶囊研究了口服exendin-4制剂。在体内溶出度研究中，发现肠溶胶囊在胃中时保持完整。胶囊完全溶解在小肠的近端，然后释放内装物。口服含有exexin-4的NPs的胶囊在治疗后5小时显示最大血浆浓度。相对于皮下对应物，其生物利​​用度为14.0±1.8％。被吸收的exendin-4可以刺激胰岛素分泌并提供延长的降糖作用。前述结果表明，开发的口服可用的exendin-4制剂值得进一步探索，作为糖尿病患者的潜在疗法。

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