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首页> 外文会议>The 6'th International Forum on Post-genome Technologies(6'IFPT)（第六届国际后基因组生命科学技术学术论坛） >OVEREXPRESSION OF HEPATIC NF-KB AND ITS CLINICAL IMPLICATIONS IN HBV-RELATED HEPOTOCELLUIAR CARCINOMA
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OVEREXPRESSION OF HEPATIC NF-KB AND ITS CLINICAL IMPLICATIONS IN HBV-RELATED HEPOTOCELLUIAR CARCINOMA

机译：肝NF-κB在HBV相关肝细胞癌中的过表达及其临床意义

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Objective: To investigate the NF-κB expression in HBV-related HCC and evaluate its clinical implications. Methods NF-κB expression was detected in HCC and their corresponding tissues. Hepatic HBV-DNA was detected by in situ molecular hybridization. Total RNA were abstracted and NF-κBmRNA were amplified by real-time-PCR. The relationship was analyzed between NF-κB and HBV. Results Positive NF-κB was brown granule-like and localized in nucleus and cytoplasm in HCC with stronger expression, and only in cytoplasm in its surrounding tissues. Its incidence was 100% in HCC, and 68. 6% in their surrounding tissues. Significant difference was found between the two groups. None of the other variables positive relationship presented between NF-κB and differentiation grade, number or size of tumor or AFP. NF-κB in HBV-DNA-positive HCC was significantly higher than that in HBV-DNA-negative ones. Conclusion NF-κB was closely associated with the HBV-related HCC and could be a marker for development of HCC.
机译：目的：探讨HBV相关性肝癌中NF-κB的表达及其临床意义。方法在肝癌及癌旁组织中检测NF-κB的表达。通过原位分子杂交检测肝HBV-DNA。通过实时PCR提取总RNA并扩增NF-κBmRNA。分析了NF-κB与HBV的关系。结果阳性NF-κB呈褐色颗粒状，位于肝癌的细胞核和细胞质中，表达较强，仅在其周围组织的细胞质中表达。其在肝癌中的发生率为100％，在其周围组织中为68.6％。两组之间存在显着差异。 NF-κB与分化程度，肿瘤或AFP的数量或大小之间没有其他正相关的变量。 HBV-DNA阳性肝癌患者的NF-κB明显高于HBV-DNA阴性肝癌患者。结论NF-κB与HBV相关的肝癌密切相关，可能是肝癌发展的标志。

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