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首页> 外文会议>8th International conference on fate and effects of pulp and paper mill effluents and 10th IWA symposium on forest industry wastewater 2012 >Androgens and fifth effect evaporator condensates do not cause similar responses in mummichog (Fundulus heteroclitus)
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Androgens and fifth effect evaporator condensates do not cause similar responses in mummichog (Fundulus heteroclitus)

机译：雄激素和五效蒸发器冷凝物不会在木乃伊（Fundulus heteroclitus）中引起类似的响应

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Studies at Irving Pulp and Paper Ltd, a bleached kraft mill in Saint John, New Brunswick, Canada, have successfully identified an in-mill waste stream (5th effect evaporator condensates) as containing endocrine disrupting substances (EDSs). These EDSs affect levels of reproductive steroids in a native estuarine fish, the mummichog or killifish (Fundulus heteroclitus). To chemically isolate suspect EDSs, a solid phase extraction protocol was used in 2009 to generate four chemically-distinct fractions, along with residual condensates. Contrary to previous work, there was no significant response in fish exposed to 4% (v/v) whole condensates, making interpretation of specific fractions impossible. The most compelling explanation in the variability of condensate effects over time is change in the chemical make-up of the condensates. Chemical fingerprinting of the condensate batch found a higher androgenic potency in the fractionation condensates than a previous exposure in 2009 that elicited plasma testosterone depressions in males at 4% (v/v). Mummichog were then exposed to model androgens methyltestosterone (100 and 1000 ng/L; MT) and dihydrotestosterone (10 and 100 μg/L; DHT). Plasma testosterone was significantly depressed by 10 μg/L DHT in males. Females had significant depression of plasma estradiol when exposed to both DHT concentrations and 1000 ng/L MT. Comparison of effects in fish exposed to pulp mill condensates and model androgens indicates androgens in the condensates may not be the source of reproductive endocrine effects in condensate-exposed mummichog. Model hormone studies of this type could help determine the classes of active compounds in reproductive-active effluents.
机译：位于加拿大新不伦瑞克省圣约翰的漂白牛皮纸造纸厂欧文纸浆和造纸有限公司的研究成功确定了含有内分泌干扰物（EDS）的厂内废物流（第5效蒸发器冷凝物）。这些EDS会影响本地河口鱼，木乃伊或奇异鱼（Fundulus heteroclitus）中生殖类固醇的水平。为了化学分离可疑的EDS，2009年采用了固相萃取方案来生成四个化学上不同的馏分以及残留的冷凝物。与以前的工作相反，暴露于4％（v / v）的全部冷凝水中的鱼没有明显反应，因此无法解释特定的馏分。凝结水效果随时间变化的最有说服力的解释是凝结水化学组成的变化。该批冷凝物的化学指纹图谱显示，分馏冷凝物中的雄激素含量高于2009年的一次暴露，后者导致男性血浆睾丸激素降低4％（v / v）。然后将Mummichog暴露于雄激素甲基睾丸激素模型（100和1000 ng / L; MT）和二氢睾丸激素（10和100μg/ L; DHT）。男性的血浆DHT被10μg/ L显着降低。当暴露于DHT浓度和1000 ng / L MT时，雌性血浆雌二醇显着降低。比较制浆厂冷凝水和模型雄激素对鱼类的影响，表明冷凝水中的雄激素可能不是暴露于冷凝水的木乃伊中生殖内分泌作用的来源。这类模型激素研究可以帮助确定生殖活性废水中的活性化合物类别。

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