• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>The 8th International Symposium on the Properties of Water, 8th, Sep 16-21, 2000, Zichron Yaakov, Israel >Different Roles of the HOG Pathway in Stress Responses of Yeast: Challenges in Understanding Osmostress Responses by Saccharomyces cerevisiae
【24h】

Different Roles of the HOG Pathway in Stress Responses of Yeast: Challenges in Understanding Osmostress Responses by Saccharomyces cerevisiae

机译：HOG途径在酵母应激反应中的不同作用：理解啤酒酵母对渗透压反应的挑战

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Baker's yeast, Saccharomyces cerevisiae, responds to decreases in extracellular water activity by increasing the production and retention of glycerol to match the higher external osmolarity. Increased glycerol retention is mediated by closing of a glycerol channel made of the protein Fpsl while the increased glycerol production response is mediated by activation of the High Osmolarity Glycerol response (HOG) pathway, an osmosensing pathway that regulates expression of glycerol synthesis enzymes. S. cerevisiae responds to an increase in extracellular water activity by activating the cell integrity pathway, a signaling pathway related to the HOG pathway. Each of these signaling pathways, containing a cascade of protein kinases, appears to be conserved among other eukaryotes, especially fungi and animals. Both the HOG and cell integrity pathways appear to react not only to osmotic stress but also to other stress signals. Thus, these two pathways together with other stress sensing pathways, e.g., the cyclic AMP pathway, coordinate the response of yeast to the complex effects of different stress. Our goal in this paper is to discuss and analyze several important findings and challenges that have arisen during the investigation of the yeast osmostress response. In this paper, we will refer to Saccharomyces cerevisiae as yeast. Also, increases in extracellular water activity will be called a hypotonic stress, decreases in extracellular water activity a hypertonic stress.
机译：贝克酵母啤酒酵母通过增加甘油的产生和保留来匹配较高的外部渗透压，从而对细胞外水活度的降低做出反应。甘油保留的增加是由蛋白质Fpsl构成的甘油通道的关闭介导的，而甘油产生反应的增加是由高渗透压甘油反应（HOG）途径的激活介导的，高渗透压的甘油反应是调节甘油合成酶表达的渗透压途径。酿酒酵母通过激活细胞完整性途径（一种与HOG途径有关的信号传导途径）来响应细胞外水活度的增加。这些包含蛋白激酶级联反应的信号通路中的每一个似乎在其他真核生物（尤其是真菌和动物）中都是保守的。 HOG和细胞完整性途径似乎不仅对渗透压反应，而且对其他压力信号也有反应。因此，这两个途径与其他应激感测途径，例如循环AMP途径一起，协调了酵母对不同胁迫的复杂作用的响应。本文的目的是讨论和分析在调查酵母渗透压反应过程中出现的一些重要发现和挑战。在本文中，我们将酿酒酵母称为酵母。另外，将细胞外水活度的增加称为低渗应激，将细胞外水活度的减少称为高渗应激。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号