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USE OF A MATHEMATICAL MODEL AS A COUNTERMEASURE TO PREVENT SPACEFLIGHT ANEMIA

机译:使用数学模型作为防止空间飞行贫血的对策

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摘要

Spaceflight results in the decrease of blood volume inrnastronauts, which then leads to a destruction of redrnblood cells causing space flight anemia upon return to arn1g environment. The mechanism for this destructionrnhas not been clearly defined and measures to preventrnred blood cell destruction do not currently exist. In thisrnstudy, we investigate the possibility of using arnmathematical model to determine the number of redrnblood cells destroyed as a result of being in arnmicrogravity environment. We have developed a modelrnusing a linear piece wise function that incorporatesrnnormal red blood cell death and reticulocyternproduction. An astronaut, using this model, would bernable compare their predicted earth normal (1g) redrnblood cell count with the actual 0g count and determinernthe number of red blood cells that have been destroyedrnas a result of being in a microgravity environment. Thisrncould then lead to the administration of erythropoietinrnto boost red blood cell production and restore the levelrnto earth normal on the final leg of the trip back to earthrnto prevent space flight anemia.
机译:太空飞行导致血流异常的减少,然后导致血红细胞的破坏,并在返回正常环境后导致太空飞行性贫血。尚未明确定义这种破坏的机制,目前尚不存在防止血红细胞破坏的措施。在这项研究中,我们研究了使用神经数学模型来确定由于处于微重力环境中而被破坏的红血细胞数量的可能性。我们开发了一个模型,该模型使用了包含正常红细胞死亡和网织红细胞生成的线性分段函数。使用该模型的宇航员可以比较其预测的地球正常(1g)红血细胞计数与实际0g计数,并确定由于处于微重力环境而被破坏的红细胞数量。然后这可能导致给予促红细胞生成素以促进红细胞的产生,并在返回地球的行程的最后一站恢复到大地正常水平,以防止太空飞行贫血。

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  • 会议地点 Versailles(FR)
  • 作者单位

    Faculty of Applied Science and Engineering, University of Toronto, Toronto, Ontario, Canada, Email: romy.seth@utoronto.ca;

    Bone and Joint Research Laboratory, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada;

    Bone and Joint Research Laboratory, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada;

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