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首页> 外文会议>ACS Symposium Series 892; Pan-Pacific Conference on Pesticide Science; 20030601-04; Honolulu,HI(US) >Development of Vaccines for the Control of Blood-Feeding Arthropods: The Combined Use of Proteomic and Genomic Strategies
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Development of Vaccines for the Control of Blood-Feeding Arthropods: The Combined Use of Proteomic and Genomic Strategies

机译：开发用于控制供血节肢动物的疫苗：蛋白质组学和基因组策略的结合使用

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摘要

Hematophagous ectoparasites and the infectious agents they transmit are of vast medical and veterinary public health importance. Control of both vectors and infectious agents is challenging due to insecticide/acaricide resistance, drug resistance, and the lack of vaccines or effective drugs for many vector-borne infectious agents. Interest in vaccine-based control of hematophagous arthropods and vector-blocking vaccines to prevent pathogen transmission continues to increase. Identification, isolation, and characterization of candidate immunogens by standard biochemical methods are highly effective approaches, but they are relatively slow and labor intensive processes. Combining genomic, especially expressed sequence tags, and proteomic approaches provides promising alternative methods for identification of vaccine candidates that complement the more traditional approaches. Increasingly, interest is being focused on pharmacologically active molecules essential for successful blood-feeding and/or pathogen transmission as candidate immunogens for novel vaccines.
机译：食血性体外寄生虫及其传播的传染原具有重要的医学和兽医公共卫生重要性。由于对杀虫剂/杀螨剂的耐药性，耐药性以及许多载体传播的传染剂缺乏疫苗或有效药物，控制载体和传染剂具有挑战性。人们对基于疫苗的控制食血节肢动物和媒介载体疫苗以防止病原体传播的兴趣不断增加。通过标准生化方法鉴定，分离和表征候选免疫原是非常有效的方法，但它们相对较慢且劳动强度大。结合基因组，尤其是表达的序列标签和蛋白质组学方法，为鉴定候选疫苗提供了有前途的替代方法，该方法可补充更传统的方法。越来越多地关注作为新疫苗的候选免疫原的成功供血和/或病原体传播必不可少的药理活性分子。

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