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首页> 外文会议>Adaptive optics and wavefront control for biological systems III >Wavefront control with a Multi-actuator Adaptive Lens in imaging applications
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Wavefront control with a Multi-actuator Adaptive Lens in imaging applications

机译：在成像应用中使用多执行器自适应透镜进行波前控制

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摘要

The use of adaptive lenses instead of deformable mirrors can simplify the implementation of an adaptive optics system. The recently introduced Multi-actuator Adaptive Lens (MAL) can be used in closed loop with a wavefront sensor to correct for time-variant wavefront aberrations. The MAL can guarantee a level of correction and a response time similar to the ones obtained with deformable mirrors. The adaptive lens is based on the use of piezoelectric actuators and, without any obstruction or electrodes in the clear aperture, can guarantee a fast response time, less than ~10ms. Our tests show that the MAL can be used both in combination with a wavefront sensor in a "classical" adaptive optics closed loop, or in a wavefront sensorless configuration. The latter has allowed us to design more compact and simple imaging systems for different microscopy platforms. We will show that the Multi-actuator Adaptive Lens has been successfully used for in-vivo OCT ophthalmic imaging in both mice and humans, as well as confocal and two photon microscopy. We tested and compared different optimization strategies such as coordinate search and the DONE algorithm. The results suggest that the MAL optimization can correct for eye aberrations with a pupil of 5mm or sample induced aberrations in microscopy.
机译：使用自适应透镜代替可变形反射镜可以简化自适应光学系统的实现。最近推出的多驱动器自适应透镜（MAL）可以与波前传感器一起在闭环中使用，以校正随时间变化的波前像差。 MAL可以保证校正水平和响应时间类似于使用可变形反射镜获得的水平。自适应透镜基于压电致动器的使用，并且在透明光圈中没有任何障碍物或电极，可以保证不到10毫秒的快速响应时间。我们的测试表明，MAL可以与“经典”自适应光学闭环中的波前传感器结合使用，也可以在无波前传感器配置中使用。后者使我们能够为不同的显微镜平台设计更紧凑，更简单的成像系统。我们将显示，多驱动器自适应透镜已成功用于小鼠和人类的体内OCT眼科成像，以及共焦和两个光子显微镜。我们测试并比较了不同的优化策略，例如坐标搜索和DONE算法。结果表明，MAL优化可以校正5mm瞳孔的眼睛像差或在显微镜下校正样品引起的像差。

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  • 来源
  • 会议地点 San Francisco(US)
  • 作者

    J. Mocci; M.Cua; S.Lee; Y.Jian; P.Pozzi; M.Quintavalla; C.Trestino; H.Verstraete; D.Wahl; R.Muradore; R.J. Zawadzki; M.Verhagen; M.V. Sarunic; S.Bonora;

  • 作者单位

    Universita di Verona, Dipartimento di Informatica, Via Le Grazie, Verona, Italy;

    School of Engineering Science, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada;

    School of Engineering Science, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada;

    School of Engineering Science, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada;

    Delft Center for Systems and Control, Delft University of Technology, Mekelweg 2, 2628 CD, Delft, Netherlands;

    CNR-Institute of Photonics and Nanotechnology, via Trasea 7, Padova, Italy;

    CNR-Institute of Photonics and Nanotechnology, via Trasea 7, Padova, Italy;

    Delft Center for Systems and Control, Delft University of Technology, Mekelweg 2, 2628 CD, Delft, Netherlands;

    School of Engineering Science, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada;

    Universita di Verona, Dipartimento di Informatica, Via Le Grazie, Verona, Italy;

    UC Davis RISE Small Animal Ocular Imaging Facility, Department of Cell Biology and Human Anatomy, University of California Davis, Davis, CA 95616, USA;

    Delft Center for Systems and Control, Delft University of Technology, Mekelweg 2, 2628 CD, Delft, Netherlands;

    School of Engineering Science, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada;

    CNR-Institute of Photonics and Nanotechnology, via Trasea 7, Padova, Italy;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Adaptive Optics; OCT; Adaptive Lens; wavefront sensorless;

    机译：自适应光学华侨城;自适应镜头无传感器波前;

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