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Noninvasive diagnosis and continuous monitoring of thrombosis in clinics by near-infrared spectroscopy

机译:利用近红外光谱技术对临床血栓形成进行无创诊断和连续监测

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摘要

Thrombosis became one of the most severe disease hazard to human health, and it incidence rate grows increasingly higher throughout the world. The conventional diagnosis and monitoring thrombosis mainly relied on the invasive techniques, e.g., digital subtraction angiography and blood sample analysis, and expensive and ionizing techniques, e.g., magnetic resonance angiography. And those techniques can not measure continuously. Here we reported our preliminary exploration of using near-infrared spectroscopy (NIRS) in clinical monitoring of thrombosis. 7 healthy subjects and 6 thrombosis patients at similar age participated the NIRS measurements of oxy- and deoxy- hemoglobin ([HbO2] and [Hb]) on 6 particular parts of legs. We repeated [HbO2] measurement at the same specified time each day after thrombolytic therapy for one single-leg-DVT patient, and terminated till the patient was cured and left hospital. We found that : (1) [HbO2] kept lower in thrombosis patients and [Hb] kept lower in healthy people (p<0.001); (2) [HbO2] kept increasing in the thrombosis leg but decreasing in healthy leg for the patients after thrombolytic therapy, and coincidently, [HbO2] acted consistent just when the patients were cured and left. Our study successfully extended the application of NIRS in noninvasive, continuous, and low-cost monitoring of thrombosis in clinics. Our findings showed the powerful potential of [HbO2] by NIRS in diagnosis and therapeutic effect evaluation of thrombosis.
机译:血栓形成已成为危害人类健康的最严重疾病之一,其发病率在世界范围内越来越高。常规的诊断和监测血栓形成主要依赖于侵入性技术,例如数字减影血管造影和血样分析,以及昂贵且电离的技术,例如磁共振血管造影。而且这些技术无法连续测量。在这里,我们报告了在临床监测血栓形成中使用近红外光谱(NIRS)的初步探索。 7名健康受试者和6名年龄相似的血栓形成患者参加了对6个腿部特定部位的氧和血红蛋白([HbO2]和[Hb])的NIRS测量。溶栓治疗后,我们每天在指定的同一时间重复测量[HbO2],治疗一名单腿DVT患者,并终止治疗直至患者治愈并离开医院。我们发现:(1)在血栓形成患者中[HbO2]保持较低水平,在健康人中[Hb]保持较低水平(p <0.001); (2)溶栓治疗后,血栓形成腿中的[HbO2]持续增加,而健康腿中的[HbO2]保持下降,同时[HbO2]刚好在患者康复和离开时表现一致。我们的研究成功地将NIRS的应用扩展到了无创,连续和低成本的临床血栓形成监测中。我们的发现表明,NIRS的[HbO2]在血栓形成的诊断和治疗效果评估中具有强大的潜力。

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  • 会议地点 San Francisco CA(US)
  • 作者单位

    State Key Lab of Electronic Thin Films Integrated Devices Biomedical Engineering department, University of Electronic Science Technology of China, Chengdu, China;

    State Key Lab of Electronic Thin Films Integrated Devices Biomedical Engineering department, University of Electronic Science Technology of China, Chengdu, China;

    State Key Lab of Electronic Thin Films Integrated Devices Biomedical Engineering department, University of Electronic Science Technology of China, Chengdu, China;

    State Key Lab of Electronic Thin Films Integrated Devices Biomedical Engineering department, University of Electronic Science Technology of China, Chengdu, China;

    Department of Anesthesiology and Surgical Intensive Care Unit, Xinhua Hospital, Shanghai, China;

    State Key Lab of Electronic Thin Films Integrated Devices Biomedical Engineering department, University of Electronic Science Technology of China, Chengdu, China;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    near-infrared spectroscopy; thrombosis; noninvasive diagnosis; therapeutic effect evaluation; hemoglobin;

    机译:近红外光谱血栓形成无创诊断治疗效果评估;血红蛋白;

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