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A study on the quantitative evaluation of skin barrier function

机译：皮肤屏障功能的定量评估研究

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摘要

We propose a quantitative evaluation method of skin barrier function using Optical Coherence Microscopy system (OCM system) with coherency of near-infrared light. There are a lot of skin problems such as itching, irritation and so on. It has been recognized skin problems are caused by impairment of skin barrier function, which prevents damage from various external stimuli and loss of water. To evaluate skin barrier function, it is a common strategy that they observe skin surface and ask patients about their skin condition. The methods are subjective judgements and they are influenced by difference of experience of persons. Furthermore, microscopy has been used to observe inner structure of the skin in detail, and in vitro measurements like microscopy requires tissue sampling. On the other hand, it is necessary to assess objectively skin barrier function by quantitative evaluation method. In addition, non-invasive and nondestructive measuring method and examination changes over time are needed. Therefore, in vivo measurements are crucial for evaluating skin barrier function. In this study, we evaluate changes of stratum corneum structure which is important for evaluating skin barrier function by comparing water-penetrated skin with normal skin using a system with coherency of near-infrared light. Proposed method can obtain in vivo 3D images of inner structure of body tissue, which is non-invasive and non-destructive measuring method. We formulate changes of skin ultrastructure after water penetration. Finally, we evaluate the limit of performance of the OCM system in this work in order to discuss how to improve the OCM system.
机译：我们提出了一种使用光学相干显微镜系统（OCM系统）和近红外光相干性的皮肤屏障功能的定量评估方法。有很多皮肤问题，例如瘙痒，刺激等。已经认识到皮肤问题是由皮肤屏障功能的损害引起的，其防止了各种外部刺激的损害和水分的流失。为了评估皮肤屏障功能，通常的策略是观察皮肤表面并询问患者皮肤状况。该方法是主观判断，并且受人的经验差异的影响。此外，显微镜已被用于详细观察皮肤的内部结构，并且诸如显微镜的体外测量需要组织采样。另一方面，需要通过定量评价方法客观地评价皮肤屏障功能。另外，需要非侵入性和非破坏性的测量方法以及随时间变化的检查。因此，体内测量对于评估皮肤屏障功能至关重要。在这项研究中，我们通过使用具有近红外光相干性的系统将透水皮肤与正常皮肤进行比较，来评估角质层结构的变化，这对于评估皮肤屏障功能至关重要。所提出的方法可以获取体内组织内部结构的3D图像，这是一种无创，无损的测量方法。我们制定透水后皮肤超微结构的变化。最后，我们在这项工作中评估了OCM系统的性能极限，以讨论如何改进OCM系统。

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  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    Tomomi Maruyama; Yasuhiro Kabetani; Michiko Kido; Kenji Yamada; Hirotoshi Oikaze; Yohei Takechi; Tomotaka Furuta; Shoichi Ishii; Haruna Katayama; Hieyong Jeong; Yuko Ohno;

  • 作者单位

    Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka, Japan 565-0871;

    Production Engineering Laboratory, Panasonic Corporation, 2-7 Matsuba-cho, Kadoma, Osaka, Japan 571-8502;

    Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka, Japan 565-0871;

    Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka, Japan 565-0871;

    Production Engineering Laboratory, Panasonic Corporation, 2-7 Matsuba-cho, Kadoma, Osaka, Japan 571-8502;

    Production Engineering Laboratory, Panasonic Corporation, 2-7 Matsuba-cho, Kadoma, Osaka, Japan 571-8502;

    Production Engineering Laboratory, Panasonic Corporation, 2-7 Matsuba-cho, Kadoma, Osaka, Japan 571-8502;

    Production Engineering Laboratory, Panasonic Corporation, 2-7 Matsuba-cho, Kadoma, Osaka, Japan 571-8502;

    Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka, Japan 565-0871;

    Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka, Japan 565-0871;

    Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka, Japan 565-0871;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Optical Coherence Microscopy; skin barrier function; maceration;

    机译：光学相干显微镜皮肤屏障功能；浸渍;

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