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首页> 外文会议>Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIV >Time-resolved fluorescence spectroscopy for intraoperative assistance of thyroid surgery
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Time-resolved fluorescence spectroscopy for intraoperative assistance of thyroid surgery

机译：时间分辨荧光光谱术用于甲状腺手术的术中辅助

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摘要

Searching for new methods to provide information of biochemical composition and structure is critical to improve the prognosis of thyroid diseases. The use of time-resolved fluorescence techniques to detect biochemical composition and tissue structure alterations could help develop a portable, minimally invasive, and non-destructive method to assist during surgical procedures. This research looks for employ a fluorescence technique based on lifetime measurements to differentiate healthy and benign lesions from malignant thyroid tissue. We employ a wide range of excitation and chose a more appropriate region for this work: 298-300 nm; and the fluorescence decay was measured at 340-450 nm. We observed fluorescence lifetimes at 340 nm emission of 0.80±0.26 and 3.94±0.47 ns for healthy tissue; 0.90±0.24 and 4.05±0.46 ns for benign lesions; and 1.21±0.14 and 4.63±0.25 ns for malignant lesions. For 450 nm emissions, we obtain lifetimes of 0.25±0.18 and 3.99±0.39 ns for healthy tissue, 0.24±0.17 and 4.20±0.48 ns for benign lesions, 0.33±0.32 and 4.55±0.55 ns for malignant lesions. We successfully demonstrated that fluorescence lifetimes at 340 nm emission can differentiate between thyroid malignant and healthy/benign tissues.
机译：寻找新方法以提供生化成分和结构信息对于改善甲状腺疾病的预后至关重要。使用时间分辨荧光技术来检测生化成分和组织结构改变，可以帮助开发一种便携式，微创和非破坏性方法，以在外科手术过程中提供帮助。这项研究寻求采用基于寿命测量的荧光技术来区分健康和良性病变与甲状腺恶性组织。我们采用了多种激发方式，并为这项工作选择了更合适的区域：298-300 nm;并在340-450nm处测量荧光衰减。我们观察到健康组织在340 nm处的荧光寿命为0.80±0.26和3.94±0.47 ns。良性病变的0.90±0.24和4.05±0.46 ns;对于恶性病变为1.21±0.14和4.63±0.25 ns。对于450 nm发射，健康组织的寿命为0.25±0.18和3.99±0.39 ns，良性病变的生命为0.24±0.17和4.20±0.48 ns，恶性病变的生命为0.33±0.32和4.55±0.55 ns。我们成功地证明了340 nm发射的荧光寿命可以区分甲状腺恶性组织和健康/良性组织。

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  • 会议地点 San Francisco CA(US)
  • 作者

    L. Bachmann; M. P. Brandao; R. Iwakura; F. S. Basilio; K. Haleplian; A. S. Ito; L. C. Conti de Freitas;

  • 作者单位

    Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Departamento de Fisica. Av. Bandeirantes 3900, Ribeirao Preto, SP - Brazil, 14040-901;

    Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Departamento de Fisica. Av. Bandeirantes 3900, Ribeirao Preto, SP - Brazil, 14040-901;

    Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Departamento de Oftalmo, Otorrino e Cirurgia de Cabeca e Pescoco. Av. Bandeirantes 3900, Ribeirao Preto, SP - Brazil, 14040-901;

    Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Departamento de Oftalmo, Otorrino e Cirurgia de Cabeca e Pescoco. Av. Bandeirantes 3900, Ribeirao Preto, SP - Brazil, 14040-901;

    Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Departamento de Fisica. Av. Bandeirantes 3900, Ribeirao Preto, SP - Brazil, 14040-901;

    Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Departamento de Fisica. Av. Bandeirantes 3900, Ribeirao Preto, SP - Brazil, 14040-901;

    Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Departamento de Oftalmo, Otorrino e Cirurgia de Cabeca e Pescoco. Av. Bandeirantes 3900, Ribeirao Preto, SP - Brazil, 14040-901;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Lifetime fluorescence; fluorescence spectroscopy; thyroid; lesions; optical diagnosis; Time-resolved fluorescence spectroscopy; absorbance; intraoperative assistance;

    机译：终身荧光；荧光光谱甲状腺;病变光学诊断时间分辨荧光光谱法；吸光度术中协助;

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