• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIV >Image-guided Cold Atmosphere Plasma (CAP) Therapy for Cutaneous Wound
【24h】

Image-guided Cold Atmosphere Plasma (CAP) Therapy for Cutaneous Wound

机译：皮肤伤口的图像引导冷大气血浆（CAP）治疗

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Bacterial infection is one of the major factors contributing to the compromised healing in chronic wounds. Sometimes bacteria biofilms formed on the wound are more resistant than adherent bacteria. Cold atmosphere plasma (CAP) has already shown its potential in contact-free disinfection, blood coagulation, and wound healing. In this study, we integrated a multimodal imaging system with a portable CAP device for image-guided treatment of infected wound in vivo and evaluated the antimicrobial effect on Pseudomonas aeruginosa sample in vitro. 15 ICR mice were divided into three groups for therapeutic experiments:(1) control group with no infection nor treatment (2) infection group without treatment (3) infection group with treatment. For each mouse, a three millimeters punch biopsy was created on the dorsal skin. Infection was induced by Staphylococcus aureus inoculation one day post-wounding. The treated group was subjected to CAP for 2 min daily till day 13. For each group, five fixed wounds' oxygenation and blood perfusion were evaluated daily till day 13 by a multimodal imaging system that integrates a multispectral imaging module and a laser speckle imaging module. In the research of relationship between therapeutic depth and sterilization effect on P.aeruginosa in agarose, we found that the CAP-generated reactive species reached the depth of 26.7μm at 30s and 41.6μm at 60s for anti-bacterial effects. Image-guided CAP therapy can be potentially used to control infection and facilitate the healing process of infected wounds.
机译：细菌感染是导致慢性伤口愈合不良的主要因素之一。有时，在伤口上形成的细菌生物膜比粘附细菌更具抵抗力。冷空气等离子体（CAP）已经显示出其在非接触式消毒，血液凝固和伤口愈合中的潜力。在这项研究中，我们将多模式成像系统与便携式CAP设备集成在一起，以在体内对感染的伤口进行图像引导治疗，并评估了对铜绿假单胞菌样品的体外抗菌作用。将15只ICR小鼠分为三组进行治疗实验：（1）既不进行感染也不进行治疗的对照组（2）不进行治疗的感染组（3）进行治疗的感染组。对于每只小鼠，在背侧皮肤上进行三毫米的穿孔活检。伤后一天通过金黄色葡萄球菌接种诱导感染。接受治疗的组每天接受CAP 2分钟，直到第13天。对于每个组，通过集成多光谱成像模块和激光散斑成像模块的多峰成像系统，每天评估5个固定伤口的氧合和血液灌注。 。在研究深度与琼脂糖中对铜绿假单胞菌杀菌效果之间关系的研究中，我们发现CAP产生的活性物质在30s达到26.7μm的深度，在60s达到41.6μm的抗菌作用。图像引导CAP治疗可潜在地用于控制感染并促进感染伤口的愈合过程。

著录项

  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    Zelin Yu; Wenqi Ren; Qi Gan; Jiahong Li; XiangXiang Li; Shiwu Zhang; Fan Jin; Cheng Cheng; Yue Ting; Ronald X. Xu;

  • 作者单位

    School of Engineering Science, University of Science and Technology of China, Hefei, China;

    School of Engineering Science, University of Science and Technology of China, Hefei, China,Department of Biomedical Engineering, The Ohio State University, Columbus, OH;

    School of Engineering Science, University of Science and Technology of China, Hefei, China;

    National Laboratory for Physical Sciences at the Microscale, Hefei, China;

    School of Engineering Science, University of Science and Technology of China, Hefei, China;

    School of Engineering Science, University of Science and Technology of China, Hefei, China;

    National Laboratory for Physical Sciences at the Microscale, Hefei, China;

    Institute of Plasma Physics Chinese Academy of Sciences, China;

    School of Life Science, University of Science and Technology of China, Hefei, China;

    School of Engineering Science, University of Science and Technology of China, Hefei, China,Department of Biomedical Engineering, The Ohio State University, Columbus, OH;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Cutaneous wound; cold atmospheric plasma; multimodal imaging system; sterilization;

    机译：皮肤伤口；冷大气等离子体多峰成像系统；消毒;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号