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首页> 外文会议>Advanced Biomedical and Clinical Diagnostic Systems III; Progress in Biomedical Optics and Imaging; vol.6 no.7 >Instrumentation for the measurement of Autofluorescence in the Human Skin
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Instrumentation for the measurement of Autofluorescence in the Human Skin

机译：人体皮肤自发荧光测量仪器

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A setup to measure skin autofluorescence was developed to assess accumulation of advanced glycation endproducts (AGE) in patients noninvasively. The method applies direct blacklight tube illumination of the skin of the lower arm, and spectrometry. The setup displays skin autofluorescence (AF) as a ratio of mean intensities detected from the skin between 420-600 nm and 300-420 nm, respectively. In an early clinical application in 46 and control subjects matched for age and gender, AF was significantly increased in the patients (p = 0.015), and highly correlated with skin AGE's that were determined from skin biopsies in both groups. A large follow-up study on type 2 diabetes mellitus, ongoing since 2001 with more than 1000 subjects, aims to assess the value of the instrument in predicting chronic complications of diabetes. At baseline, a relation with age, glycemic status and with complications present was found. In a study in patients with end stage renal disease on dialysis AF was a strong and independent predictor of total and cardiovascular mortality. A commercial version of this AGE-reader is now under development and becomes available early 2005 (DiagnOptics B.V., Groningen, The Netherlands). One of the remaining questions, that will be answered by measuring so-called Exciation-Emission Matrices (EEM's) of the skin tissue in vivo, is whether a more selective choice of wavelengths is more strongly related to clinical characteristics. An experimental instrument to measure these EEM's was, therefore, developed as well. Clinical measurements are underway of EEM's in patient groups with diabetes mellitus and in healthy volunteers.
机译：开发了一种用于测量皮肤自发荧光的设置，以评估无创患者中晚期糖基化终产物（AGE）的积累。该方法对下臂的皮肤直接应用黑光灯管照明，并进行光谱分析。该设置将皮肤自发荧光（AF）显示为从皮肤检测到的平均强度分别在420-600 nm和300-420 nm之间的比率。在针对年龄和性别匹配的46位对照受试者的早期临床应用中，患者的AF显着增加（p = 0.015），并且与两组的皮肤活检确定的皮肤AGE高度相关。自2001年以来，一项针对2型糖尿病的大型后续研究一直在进行，涉及1000多个受试者，旨在评估该仪器在预测糖尿病慢性并发症中的价值。在基线时，发现与年龄，血糖状况和存在的并发症有关。在一项针对终末期肾脏疾病透析患者的研究中，AF是总死亡率和心血管疾病死亡率的有力且独立的指标。这种AGE阅读器的商业版本目前正在开发中，并将于2005年初上市（DiagnOptics B.V.，荷兰格罗宁根）。剩下的问题之一，是通过测量体内皮肤组织的所谓激发-发射矩阵（EEM's）来回答的，是波长的更具选择性的选择是否与临床特征更密切相关。因此，还开发了一种测量这些EEM的实验仪器。在患有糖尿病的患者组和健康志愿者中正在进行EEM的临床测量。

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