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首页> 外文会议>Advanced Biomedical and Clinical Diagnostic Systems III; Progress in Biomedical Optics and Imaging; vol.6 no.7 >Research results on biomagnetic imaging of the lung tumors
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Research results on biomagnetic imaging of the lung tumors

机译：肺肿瘤生物磁成像的研究成果

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摘要

Recent results on the development and implementation of a novel technology for lung tumor detection and imaging is presented. This technology offers high-sensitivity imaging of magnetic nanoparticles to provide specific diagnostic images of early lung tumors and potential distant metastases. Recent developments in giant magnetostrictive (GMS) or magnetic shape memory (MSM) materials have led to the possibility of developing small, low-cost, room-temperature, portable, high-sensitivity, fiber-optic sensors capable of robustly detecting magnetic nanoparticles, without direct contact with the skin. Magnetic nanoparticles are conjugated with antibodies, which target them to lung tumors. A prototype fiber-optic biomagnetic sensor, based on giant magnetostrictive or magnetic shape memory materials, with the requisite sensitivity to image the magnetic signals generated by antibody-labeled magnetic nanoparticles in lung tumors has been built and calibrated. The uniqueness of the biomagnetic sensor lies in the fact that it offers high sensitivity at room temperature, and is not a SQUID-based system. The results obtained during the process of choosing the right magnetostrictive materials are presented. Then, for the construction of an accurate image of the lung tumor, the optimum spatial distribution of one-channel sensors and nanoparticle polarization has been analyzed.
机译：提出了开发和实施一种新的肺肿瘤检测和成像技术的最新结果。这项技术可对磁性纳米粒子进行高灵敏度成像，以提供早期肺部肿瘤和潜在远处转移的特定诊断图像。巨磁致伸缩（GMS）或磁性形状记忆（MSM）材料的最新发展导致开发小型，低成本，室温，便携式，高灵敏度的光纤传感器的可能性成为可能，这些传感器能够牢固地检测磁性纳米粒子，不直接接触皮肤。磁性纳米颗粒与抗体缀合，将其靶向肺肿瘤。基于巨磁致伸缩或磁性形状记忆材料的原型光纤生物磁传感器具有必要的灵敏度，可以对肺肿瘤中抗体标记的磁性纳米颗粒产生的磁信号成像，并进行了校准。生物磁传感器的独特性在于它在室温下具有很高的灵敏度，而不是基于SQUID的系统。介绍了在选择正确的磁致伸缩材料的过程中获得的结果。然后，为了构建准确的肺肿瘤图像，分析了单通道传感器的最佳空间分布和纳米粒子极化。

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