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Tri-modal confocal margin screening for the presence of residual squamous cell carcinoma in Mohs surgical excisions

机译：三模式共聚焦切缘筛查Mohs手术切除中是否残留鳞状细胞癌

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摘要

Screening cancer in excision margins may be done with confocal microscopy to save time and cost over the gold standard histopathology (H&E). However, diagnostic accuracy requires sufficient contrast. Reflectance mode enables detection of large (>500um) nodular tumors. Enhanced nuclear contrast with acridine orange fluorescence mode additionally enables detection of tiny (<50um) basal cell carcinomas. Here, we present a novel combination of three modes to detect squamous cell carcinoma (SCC). Accurate screening of SCC requires eosin fluorescence, reflectance and acridine orange fluorescence to enable contrast for cytoplasm, collagen and nuclei respectively. Combining these signals replicates H&E for rapid clinical translation.
机译：可以用共聚焦显微镜对切除边缘的癌症进行筛查，以节省金标准组织病理学（H＆E）的时间和成本。但是，诊断准确性需要足够的对比度。反射模式可检测大型（> 500um）结节性肿瘤。带有a啶橙荧光模式的增强核反差还可以检测微小（<50um）的基底细胞癌。在这里，我们提出了三种模式的新型组合，以检测鳞状细胞癌（SCC）。准确筛查SCC需要曙红荧光，反射率和a啶橙荧光才能分别对细胞质，胶原蛋白和细胞核进行对比。组合这些信号可复制H＆E，以快速进行临床翻译。

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  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    Anna Bar; Nicholas Snavely; Nathaniel Chen; Steven Jacques; Daniel S. Gareau;

  • 作者单位

    Oregon Health Science University, Departments of Dermatology , CH16D, 3303 SW Bond Avenue, Portland, OR 97239, USA;

    Oregon Health Science University, Departments of Dermatology , CH16D, 3303 SW Bond Avenue, Portland, OR 97239, USA;

    Biomedical engineering, CH16D, 3303 SW Bond Avenue, Portland, OR 97239, USA;

    Oregon Health Science University, Departments of Dermatology , CH16D, 3303 SW Bond Avenue, Portland, OR 97239, USA,Biomedical engineering, CH16D, 3303 SW Bond Avenue, Portland, OR 97239, USA;

    Oregon Health Science University, Departments of Dermatology , CH16D, 3303 SW Bond Avenue, Portland, OR 97239, USA,Biomedical engineering, CH16D, 3303 SW Bond Avenue, Portland, OR 97239, USA;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医用物理学;
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