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首页> 外文会议>Advances in environment, computational chemistry amp; bioscience >In Silico Study of MicroRNA-Regulated Protein-Protein Interaction Modules in Human Disease and Plant Infected with Pathogen Systems
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In Silico Study of MicroRNA-Regulated Protein-Protein Interaction Modules in Human Disease and Plant Infected with Pathogen Systems

机译：在人类疾病和病原体系统感染的植物中，MicroRNA调控的蛋白质-蛋白质相互作用模块的计算机模拟研究

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摘要

Living organisms are continuously subjected to infection by pathogens including bacteria and viruses. In general, a pathogen invades host in many ways. Many of such mechanisms involve protein-protein interactions (PPIs) in the host. PPIs are fundamental in every aspect of functions of living cells. It plays a crucial role in the infection processes, some critical inter-species interactions such as host-pathogen interactions and pathogenicity occur through PPIs. A strategy to gain a better understanding into the interaction and function of these proteins is to make use of the PPI data, and construct a set of interaction rules for disease proteins. MicroRNAs (miRNAs) are a class of small non-coding RNAs that bind to mRNA and induce either translation repression or mRNA degradation. There have been reports indicated that miRNAs could cause diseases in human or plant. The recent availability of both miRNA and PPI data has made it possible to study human or plant disease at a system level. In this lecture, we will discuss how to integrate the miRNA, mRNA, and PPI records to establish miRNA-regulated modules for both of human cancer and plant-pathogen systems. . This type of tool could assist users in identifying disease-related miRNA targeting pathways. It is expected that these two study cases may provide some significant information to reveal biological processes involve in both of human and plant immunity systems.
机译：活生物体不断受到包括细菌和病毒在内的病原体的感染。通常，病原体以多种方式侵入宿主。许多这样的机制涉及宿主中的蛋白质-蛋白质相互作用（PPI）。 PPI是活细胞功能各个方面的基础。它在感染过程中起着至关重要的作用，某些关键的物种间相互作用（例如宿主-病原体相互作用和致病性）通过PPI发生。一种更好地了解这些蛋白质的相互作用和功能的策略是利用PPI数据，并为疾病蛋白质构建一套相互作用规则。 MicroRNA（miRNA）是一类小的非编码RNA，它们与mRNA结合并诱导翻译抑制或mRNA降解。有报道表明，miRNA可能引起人类或植物疾病。 miRNA和PPI数据的最新可用性使在系统水平上研究人类或植物疾病成为可能。在本讲座中，我们将讨论如何整合miRNA，mRNA和PPI记录以建立针对人类癌症和植物病原体系统的miRNA调控模块。 。这种工具可以帮助用户识别与疾病相关的miRNA靶向途径。预计这两个研究案例可能会提供一些重要信息，以揭示涉及人类和植物免疫系统的生物过程。

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