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首页> 外文会议>Advances in bioceramics and porous ceramics III >BIOGLASS/CHITOSAN COMPOSITE AS A NEW BONE SUBSTITUTE
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BIOGLASS/CHITOSAN COMPOSITE AS A NEW BONE SUBSTITUTE

机译：生物玻璃/壳聚糖复合材料作为新的骨替代品

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摘要

Glasses and glass-ceramic materials based on the SiO_2-CaO-P_2O_5 system constitute an important group of materials that have found wide application in medicine as bone implants. These materials are able to bind with bone in a living organism through the formation of apatite like layer on the implant site or surface. Sol-gel processing has been successfully used in the production of a variety of materials for both biomedical and nonbiomedical applications. The room temperature synthesis of single or multicomponent oxide glasses, in which the morphological, physical, and chemical properties can be tailored by synthesis parameters, is a significant advantage of this method. Chitosan is a biocopolymer comprising of glucosamine and N-acetylglucosamine, obtained by deacetylation of chitin. It has been reported to be safe, hemostatic and osteoconductive, and to promote wound healing. New injectable, bioglass/chitosan composites was investigated in this study. The prepared composite was characterized by Fourier transform infra-red spectroscopy (FTIR), X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM). In-vivo evaluation was performed to examine the osteoconductivity of synthesized composite. In this case radiographic and pathological assays were accomplished. The objective of this study was to develop a new composite and the effect of chitosan on injectability was investigated.
机译：基于SiO_2-CaO-P_2O_5体系的玻璃和玻璃陶瓷材料构成了一组重要的材料，这些材料已在医学中广泛用作骨植入物。这些材料能够通过在植入部位或表面上形成磷灰石样层而与生物体内的骨骼结合。溶胶-凝胶加工已成功用于生物医学和非生物医学应用的各种材料的生产中。该方法的显着优点是可以通过合成参数调整形态，物理和化学性质的单组分或多组分氧化物玻璃的室温合成。壳聚糖是包含葡糖胺和N-乙酰基葡糖胺的生物共聚物，其是通过几丁质的脱乙酰化而获得的。据报道它是安全，止血和骨传导性的，并能促进伤口愈合。在这项研究中研究了新型可注射生物玻璃/壳聚糖复合材料。通过傅立叶变换红外光谱（FTIR），X射线衍射分析（XRD）和扫描电子显微镜（SEM）对制备的复合材料进行表征。进行体内评估以检查合成复合材料的骨传导性。在这种情况下，完成了射线照相和病理分析。这项研究的目的是开发一种新的复合材料，并研究了壳聚糖对注射性的影响。

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  • 来源
  • 会议地点 Daytona Beach FL(US);Daytona Beach FL(US)
  • 作者

    P. Khoshakhlagh; F. Moztarzadeh; S. M. Rabiee; R.Moradi; P.Heidari; R. Ravarian; S. Amanpour;

  • 作者单位

    Department of Biomedical Engineering, Amirkabir University of technology, Hafiz Ave.. Tehran, Iran;

    rnDepartment of Biomedical Engineering, Amirkabir University of technology, Hafiz Ave.. Tehran, Iran;

    rnOil Hospital, Hafiz Ave., Tehran, Iran;

    rnDepartment of Mechanic Engineering, Babol (Noshirvani) University of Technology, Babol, Iran;

    Imam Khomeini Hospital, Keshavarz Blvd., Tehran, Iran;

    rnDepartment of Biomedical Engineering, Amirkabir University of technology, Hafiz Ave.. Tehran, Iran;

    rnImam Khomeini Hospital, Keshavarz Blvd., Tehran, Iran;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物材料学;
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