• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Advances in bioceramics and porous ceramics III >BIODEGRADABLE RARE EARTH LITHIUM ALUMINOBORATE GLASSES FOR BRACHYTHERAPY USE
【24h】

BIODEGRADABLE RARE EARTH LITHIUM ALUMINOBORATE GLASSES FOR BRACHYTHERAPY USE

机译：可生物降解的稀土铝硼酸盐玻璃，用于胸腔治疗

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Rare earth lithium aluminoborate (RELAB) glasses containing dysprosium (Dy) or holmium (Ho) were investigated to determine their suitability for irradiating diseased organs in the body; i.e., brachytherapy. The chemical durability of a glass used for brachytherapy is especially important since none of the radioactive Dy or Ho should escape from the glass, but in some applications the glass should eventually degrade in the body. The chemical durability (dissolution rate) of Dy or Ho containing glass microspheres (20 to 40 microns in diameter) immersed in phosphate buffered saline (PBS) or DI water at 37℃ was measured as a function of their alumina content, 5 to 20 mole percent. A highly desirable aspect of the Dy or Ho lithium aluminoborate glasses is that they degraded in PBS or DI water in a non-uniform way such that the radioisotope was confined to the remnants of the corroded microsphere. Dy microspheres injected into the stifle (knee) joint of a rat were noticeably corroded after two weeks. The in-vivo results indicate that RELAB microspheres can safely deliver localized doses of beta radiation to diseased organs and should eventually be cleared from the body.
机译：研究了含有（Dy）或（Ho）的稀土铝硼酸锂玻璃（RELAB），以确定它们是否适合辐照体内患病的器官；即近距离放射疗法。用于近距离放射治疗的玻璃的化学耐久性特别重要，因为放射性Dy或Ho都不会从玻璃中逸出，但是在某些应用中，玻璃最终会在体内降解。浸渍在37℃的磷酸盐缓冲液（PBS）或去离子水中的含Dy或Ho的玻璃微球（直径为20至40微米）的化学耐久性（溶解速率）是其氧化铝含量（5至20摩尔）的函数百分。 Dy或Ho铝硼酸锂玻璃的一个非常理想的方面是，它们在PBS或去离子水中的降解方式不均匀，从而放射性同位素被限制在被腐蚀的微球体的残留物中。两周后，注入到大鼠膝关节中的Dy微球被明显腐蚀。体内结果表明RELAB微球可以安全地向患病器官输送局部剂量的β射线，最终应从体内清除。

著录项

  • 来源
  • 会议地点 Daytona Beach FL(US);Daytona Beach FL(US)
  • 作者

    J.E. White; D. E. Day; R.F. Brown; G.J. Ehrhardt;

  • 作者单位

    Praxair Inc., Tonawanda, NY 14150;

    rnDepartment of Materials Science and Engineering, , Missouri University of Science and Technology, Rolla, MO 65409;

    rnDepartment of Biological Sciences, Missouri University of Science and Technology, Rolla, MO 65409;

    rnUniversity of Missouri Research Reactor, University of Missouri-Columbia, MO 65211;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物材料学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号