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首页> 外文会议>Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing >Process of thermal destruction of glucose in consequence of sterilization in autoclave in the biopharmaceutical manufacturing
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Process of thermal destruction of glucose in consequence of sterilization in autoclave in the biopharmaceutical manufacturing

机译：生物制药生产中高压灭菌器灭菌导致葡萄糖热破坏的过程

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Abstract: The results of studying the process of glucose' thermal decomposition in consequence of the sterilization in the autoclave and the shelf life are considered. The research of the process was carried out for 5% glucose solution for injections before and after the sterilization in the autoclave by saturated steam at 110$DGR@C for 30 minutes by the study of UV absorption spectra, granulometric analysis in the interval 0.2 - 25.0 mkm and pH measurements. The spectra of the glucose solutions before the sterilization were found to have no absorption bands in the range from 200 nm to 400 nm. After the sterilization two absorption bands with maximal at 229 nm and 284 nm respectively appeared. After three-month storage only one absorption band with maximum at 284 nm remains. In the report the observed spectral effects are explained.!4
机译：摘要：研究了高压灭菌锅中葡萄糖的热分解过程和货架期的研究结果。通过紫外吸收光谱的研究，在0.2-区间内进行粒度分析，对5％葡萄糖溶液的注射液在高压釜中以饱和蒸汽在110 $ DGR @ C下灭菌30分钟进行了工艺研究。 25.0英里/小时和pH值测量。发现灭菌之前的葡萄糖溶液的光谱在200nm至400nm的范围内没有吸收带。灭菌后，出现两个最大在229 nm和284 nm处的吸收带。储存三个月后，仅保留一个最大吸收波长为284 nm的吸收带。在报告中解释了观察到的光谱效应。！4

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