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首页> 外文会议>Advances in optics for biotechnology, medicine and surgery XV >IMAGING MOVING TARGETS THROUGH SCATTERING MEDIA
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IMAGING MOVING TARGETS THROUGH SCATTERING MEDIA

机译：通过散射介质成像移动目标

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Imaging in turbid media such as biological tissue is challenging primarily due to light scattering, which degrades resolution and limits the depths at which we can reliably image objects. There are two main approaches for realizing non-destructive optical imaging through scattering tissue: gated approaches, which serve to distinguish and reject the multiply scattered photons; and non-gated approaches, which detect both the unscattered and scattered light contributions, and leverage the information from the scattering process in order to image the object. In terms of non-gated approaches, both wavefront shaping (WFS) and speckle-correlation-based imaging (SCI) techniques can achieve high-resolution imaging of objects hidden within scattering media. WFS techniques exploit the principles of time-reversal to undo the effects of scattering, whereas SCI methods exploit the angular correlations inherent within the scattering process to reconstruct the hidden object. In contrast with WFS approaches, SCI methods do not need long acquisition times or the presence of a guide star. However, SCI methods are currently limited to imaging sparsely tagged objects in a dark-field scenario, and are strongly impacted by noise from other sources. In this work, we establish a technique that allows SCI to image obscured objects in a bright-field scenario. Our technique leverages the temporal correlations inherent in the scattering process to distinguish the object signal from the remaining, undesired 'background' light contributions. By using a deterministic phase modulator to generate a spatially incoherent light source, the background light contribution is kept constant between different acquisitions and can subsequently be subtracted out. As long as the object moves between acquisitions, the signal from the object can be isolated. The object can be reconstructed from this signal with high fidelity. Using this technique, we experimentally demonstrate successful reconstruction of moving objects hidden behind and between optically translucent materials. Due to the ability to effectively isolate the object signal, our work is not limited to imaging objects in the dark-field case, but also works in bright-field scenarios, with non-emitting objects. This ability opens up many potential applications for imaging in scattering media, such as through turbulent atmosphere or biological tissue, and makes this work relevant to the technical session on 'Biophotonics in scattering tissue.
机译：在诸如生物组织之类的混浊介质中成像的挑战主要在于光散射，这会降低分辨率并限制了我们可以可靠地对物体成像的深度。通过散射组织实现无损光学成像的主要方法有两种：门控方法，用于区分和拒绝多重散射的光子；非门控方法可以检测未散射的光和散射的光，并利用散射过程中的信息对物体成像。就非门控方法而言，波阵面成形（WFS）和基于斑点相关成像（SCI）的技术都可以实现对隐藏在散射介质中的对象的高分辨率成像。 WFS技术利用时间反转原理来消除散射的影响，而SCI方法利用散射过程中固有的角度相关性来重建隐藏对象。与WFS方法相反，SCI方法不需要很长的采集时间或导星的存在。但是，SCI方法目前仅限于在暗视场中对稀疏标记的对象进行成像，并且受到其他来源的噪声的强烈影响。在这项工作中，我们建立了一种技术，该技术可以使SCI在明视野中对被遮挡的物体成像。我们的技术利用了散射过程中固有的时间相关性，将物体信号与剩余的，不需要的“背景”光贡献区分开。通过使用确定性相位调制器生成空间上不相干的光源，背景光的贡献在不同采集之间保持恒定，并且可以随后减去。只要对象在两次采集之间移动，就可以隔离来自对象的信号。可以从该信号以高保真度重建对象。使用这种技术，我们通过实验证明了隐藏在光学半透明材料后面和之间的运动对象的成功重建。由于能够有效隔离对象信号，因此我们的工作不仅限于在暗场中对对象成像，而且还适用于带有非发射对象的明场场景。这种能力为在散射介质中成像（例如通过湍流的大气或生物组织）开辟了许多潜在的应用领域，并使这项工作与“散射组织中的生物光子学”技术会议相关。

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