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首页> 外文会议>Advances in photonics of quantum computing, memory, and communication VI >Nanodiamond imaging: molecular imaging with optically-detected spin resonance of nitrogen-vacancy centers in nanodiamonds
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Nanodiamond imaging: molecular imaging with optically-detected spin resonance of nitrogen-vacancy centers in nanodiamonds

机译：纳米金刚石成像：分子成像与光学检测到的纳米金刚石中氮空位中心的自旋共振

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Nanodiamond imaging is a new molecular imaging modality that takes advantage of nitrogen-vacancy (NV) defects in nanodiamonds to image the distribution of nanodiamonds within a living organism with high sensitivity and high resolution. Nanodiamond is a nontoxic material that is easily conjugated to biomolecules, such that the distribution of nanodiamond within a living organism can be used to elicit physiological information. Unlike the tracers used in other molecular imaging modalities such as positron emission tomography (PET) and single photon emission computed tomography (SPECT), nanodiamonds are stable and thus allow longitudinal imaging of the same organism over a long time span. Unlike fluorescence-based molecular imaging that has a resolution degraded by photon scattering, the resolution of nanodiamond imaging is defined by the strength of a magnetic gradient. To form an image, a magnetic field-free region is created, such as exists halfway between two identical magnets with north poles facing each other. Optical excitation pumps the NVs into a bright fluorescence state, and microwaves transfer them to a dark state, but only for those NVs within the field-free region and resonant with the microwaves. By rastering the field-free region across the sample, the changes in fluorescence yield the nanodiamond concentration. Images of nanodiamond phantoms within chicken breast have been recorded with a prototype system. By modifying the nanodiamond particles and enhancing the imaging system, it should be possible to approach 100 urn resolution and to increase the sensitivity to a 10 nanomolar carbon concentration per root Hz in a mm~3 voxel.
机译：纳米金刚石成像是一种新的分子成像方式，它利用纳米金刚石中的氮空位（NV）缺陷来以高灵敏度和高分辨率对纳米金刚石在活生物体内的分布进行成像。纳米金刚石是一种容易与生物分子结合的无毒材料，因此纳米金刚石在活生物体内的分布可用于引发生理信息。与其他分子成像方式（如正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT））中使用的示踪剂不同，纳米金刚石是稳定的，因此可以长时间对同一生物进行纵向成像。与基于荧光的分子成像（其分辨率因光子散射而降低）不同，纳米金刚石成像的分辨率由磁梯度的强度来定义。为了形成图像，创建了一个无磁场区域，例如存在于两个相同磁体之间的北极彼此面对的中间位置。光学激发将NV泵浦到明亮的荧光状态，微波将其转移到暗状态，但仅适用于无场区内并与微波共振的NV。通过光栅化整个样品的无场区域，荧光的变化产生了纳米金刚石的浓度。鸡胸腔内的纳米金刚石幻像的图像已通过原型系统记录下来。通过修饰纳米金刚石颗粒并增强成像系统，应该有可能达到100微米分辨率，并提高mm〜3体素中每根Hz的10纳摩尔碳浓度的灵敏度。

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