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首页> 外文会议>Advances in regenerative medicine: Role of nanotechnology. and engineering principles >Chapter 16 Nano-engineered Thin Films for Cell and Tissue-Contacting Applications
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Chapter 16 Nano-engineered Thin Films for Cell and Tissue-Contacting Applications

机译：第十六章用于细胞和组织接触应用的纳米工程薄膜

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摘要

Thin films of bioactive, biocompatible and biotherapeutic materials are crucial to many applications in bioengineering and medicine, but the susceptibility of these materials to thermal damage forbids the application of many conventional thin-film deposition technologies. Here we describe a novel approach to depositing thin nanostructured thin films using resonant mid-infrared laser ablation. This vapor-phase technique - which can be employed either in vacuum or in air or another ambient gas environment - circumvents many difficulties attendant to conventional liquid-phase deposition technologies, such as spin- and dip-coating. It makes possible, for example, multilayer deposition with sharp interfaces, and patterning by means of shadow-masking. Examples of the technique on biocompatible and -degradable polymers, nucleic acids, fluoropolymers and function-alized nanoparticles are described. In conclusion, current developments in laser technology are discussed that can enable this thin-film deposition technique, now based on tunable, picosecond mid-infrared free-electron lasers, to be realized using mid-infrared solid-state, table-top laser sources with similar characteristics.
机译：具有生物活性，生物相容性和生物治疗性材料的薄膜对于生物工程和医学中的许多应用至关重要，但是这些材料对热损伤的敏感性阻止了许多常规薄膜沉积技术的应用。在这里，我们描述了一种使用共振中红外激光烧蚀沉积纳米结构薄膜的新颖方法。这种气相技术-可以在真空中或在空气中或在其他环境气体环境中使用-克服了常规液相沉积技术（例如旋涂和浸涂）带来的许多困难。例如，它可以实现具有尖锐界面的多层沉积，以及通过阴影掩膜进行图案化。描述了关于生物相容性和可降解聚合物，核酸，含氟聚合物和功能化纳米颗粒的技术的实例。总之，讨论了激光技术的最新发展，可以使这种基于现在的可调谐皮秒中红外自由电子激光器的薄膜沉积技术能够使用中红外固态台式激光源实现具有相似的特征。

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